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| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alison Riske | Win | 7-6 (7-2), 5-7, 6-2 |
| Third Round | Anett Kontaveit | Loss | 6-7 (5-7), 3-6 |
| Chicago Fall Tennis Classic | ||
| Surface: Hard | Date: Sep. 27 - Oct. 3 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Shelby Rogers | Loss | 4-6, 5-7 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Viktorija Golubic | Win | 7-5, 4-6, 7-5 |
| Second Round | Lauren Davis | Win | 6-4, 6-4 |
| Third Round | Greet Minnen | Win | 6-1, 6-2 |
| Fourth Round | Maria Sakkari | Loss | 7-6 (7-2), 6-7 (6-8), 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Karolina Muchova | Loss | 4-6, 2-6 |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Harriet Dart | Win | 6-1, 3-6, 6-3 |
| Third Round | Ons Jabeur | Loss | 7-6 (7-5), 4-6, 1-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Alize Cornet | Loss | 2-6, 1-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 21 - Jun. 26 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Christina McHale | Win | 6-4, 2-6, 6-2 |
| Second Round | Anett Kontaveit | Loss | 3-6, 3-6 |
| bett1open | ||
| Surface: Grass | Date: Jun. 14 - Jun. 20 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alize Cornet | Loss | 6-7 (2-7), 5-7 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Tamara Zidansek | Loss | 7-6 (7-1), 6-7 (2-7), 7-9 |
| Internationaux de Strasbourg | ||
| Surface: Clay | Date: May 23 - May 29 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Andrea Lazaro Garcia | Win | 6-1, 6-2 |
| Second Round | Maryna Zanevska | Win | 6-1, 6-4 |
| Quarterfinals | Sorana Cirstea | Loss | Retired |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tereza Martincova | Win | 7-6 (7-5), 6-2 |
| Third Round | Amanda Anisimova | Win | 7-6 (7-4), 6-7 (2-7), 6-4 |
| Fourth Round | Garbine Muguruza | Win | 3-6, 6-3, 6-2 |
| Quarterfinals | Sara Sorribes Tormo | Win | 6-4, 3-6, 6-3 |
| Semifinals | Maria Sakkari | Win | 7-6 (9-7), 3-6, 7-6 (7-4) |
| Final | Ashleigh Barty | Loss | 3-6, 0-4 Retired |
| Phillip Island Trophy | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Madison Brengle | Win | 7-6 (7-4), 4-6, 6-3 |
| Third Round | Zarina Diyas | Win | 6-1, 0-0 Retired |
| Quarterfinals | Irina-Camelia Begu | Win | 6-3, 4-6, 7-6 (7-5) |
| Semifinals | Marie Bouzkova | Loss | 7-6 (11-9), 2-6, 5-7 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Mihaela Buzarnescu | Win | 6-2, 4-6, 6-3 |
| Second Round | Su-Wei Hsieh | Loss | 3-6, 2-6 |
