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| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Caroline Garcia | Loss | 6-7 (2-7), 7-6 (8-6), 1-6 |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 8 - Aug. 14 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sloane Stephens | Win | 6-2, 4-6, 6-2 |
| Third Round | Karolina Pliskova | Loss | 1-6, 7-6 (11-9), 3-6 |
| Mubadala Silicon Valley Classic | ||
| Surface: Hard | Date: Aug. 1 - Aug. 7 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Shelby Rogers | Loss | 1-6, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Zoe Hives | Win | 6-1, 6-4 |
| Second Round | Viktoriya Tomova | Win | 6-4, 6-3 |
| Third Round | Tatjana Maria | Loss | 3-6, 5-7 |
| Rothesay International Eastbourne | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anhelina Kalinina | Loss | 6-3, 5-7, 4-6 |
| bett1open | ||
| Surface: Grass | Date: Jun. 13 - Jun. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Leolia Jeanjean | Win | 6-3, 6-2 |
| Second Round | Daria Saville | Win | 6-1, 7-5 |
| Quarterfinals | Daria Kasatkina | Win | 6-0, 6-3 |
| Semifinals | Belinda Bencic | Loss | 7-6 (8-6), 4-6, 4-6 |
| Rothesay Open Nottingham | ||
| Surface: Grass | Date: Jun. 6 - Jun. 12 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Camila Osorio | Win | 6-2, 6-3 |
| Second Round | Rebecca Marino | Win | 1-6, 6-3, 6-3 |
| Quarterfinals | Beatriz Haddad Maia | Loss | 4-6, 6-4, 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Clara Burel | Win | 6-2, 6-3 |
| Second Round | Karolina Muchova | Loss | 6-7 (5-7), 6-7 (4-7) |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ekaterina Alexandrova | Win | 6-3, 6-2 |
| Third Round | Coco Gauff | Win | 6-4, 7-5 |
| Quarterfinals | Ons Jabeur | Loss | 6-1, 5-7, 1-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Madison Keys | Win | 6-7 (8-10), 6-3, 6-4 |
| Second Round | Daria Kasatkina | Loss | 6-3, 3-6, 1-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Laura Siegemund | Loss | 4-6, 1-3 Retired |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Beatriz Haddad Maia | Loss | 6-4, 1-6, 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Katerina Siniakova | Win | 6-3, 7-5 |
| Third Round | Petra Kvitova | Win | 6-3, 6-0 |
| Fourth Round | Daria Saville | Win | 4-1 Retired |
| Quarterfinals | Elena Rybakina | Win | 7-5, 6-4 |
| Semifinals | Paula Badosa | Win | 6-2, 4-6, 6-1 |
| Final | Iga Swiatek | Loss | 4-6, 1-6 |
| Qatar TotalEnergies Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 26 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ann Li | Win | 6-3, 6-3 |
| Third Round | Jessica Pegula | Win | 6-4, 7-5 |
| Quarterfinals | Cori Gauff | Win | 6-3, 6-3 |
| Semifinals | Iga Swiatek | Loss | 4-6, 3-6 |
| St. Petersburg Ladies' Trophy | ||
| Surface: Hard | Date: Feb. 7 - Feb. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Potapova | Win | 6-4, 6-4 |
| Second Round | Ekaterina Alexandrova | Win | 6-2, 6-4 |
| Quarterfinals | Elise Mertens | Win | 7-6 (9-7), 6-2 |
| Semifinals | Irina-Camelia Begu | Win | 6-4, 6-7 (4-7), 6-4 |
| Final | Anett Kontaveit | Loss | 7-5, 6-7 (4-7), 5-7 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Tatjana Maria | Win | 6-4, 7-6 (7-2) |
| Second Round | Qinwen Zheng | Win | 6-1, 6-4 |
| Third Round | Veronika Kudermetova | Win | 6-4, 6-1 |
| Fourth Round | Jessica Pegula | Loss | 6-7 (0-7), 3-6 |
| Adelaide International 1 | ||
| Surface: Hard | Date: Jan. 3 - Jan. 9 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Tamara Zidansek | Win | 6-2, 0-6, 6-4 |
| Second Round | Shelby Rogers | Loss | 6-7 (5-7), 6-2, 4-6 |
