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| China Open | ||
| Surface: Hard | Date: Sep. 30 - Oct. 8 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Mayar Sherif | Win | 1-6, 6-4, 7-6 (10-8) |
| Second Round | Xinyu Wang |
| Toray Pan Pacific Open Tennis Tournament | ||
| Surface: Hard | Date: Sep. 25 - Oct. 1 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Marta Kostyuk | Win | 3-6, 6-4, 6-3 |
| Second Round | Despina Papamichail | Win | 6-4, 6-4 |
| Quarterfinals | Jessica Pegula | Loss | 1-6, 0-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 9 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Alycia Parks | Win | 2-6, 6-4, 6-2 |
| Second Round | Sofia Kenin | Win | 2-6, 6-4, 6-4 |
| Third Round | Greet Minnen | Win | 6-3, 6-4 |
| Fourth Round | Aryna Sabalenka | Loss | 1-6, 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 20 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Peyton Stearns | Win | 6-2, 6-1 |
| Second Round | Varvara Gracheva | Win | 6-3, 6-1 |
| Third Round | Aryna Sabalenka | Loss | 3-6, 3-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Elise Mertens | Win | 6-4, 6-2 |
| Second Round | Anna Blinkova | Win | 6-2, 7-5 |
| Third Round | Marie Bouzkova | Win | 6-3, 6-4 |
| Quarterfinals | Elena Rybakina | Loss | 7-5, 5-7, 6-7 (8-10) |
| Palermo Ladies Open | ||
| Surface: Red Clay | Date: Jul. 17 - Jul. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Martina Trevisan | Win | |
| Second Round | Tatiana Prozorova | Win | |
| Quarterfinals | Jasmine Paolini | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 15 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Caroline Dolehide | Win | |
| Second Round | Jodie Burrage | Win | |
| Third Round | Victoria Azarenka | Loss |
| Rothesay International Eastbourne | ||
| Surface: Grass | Date: Jun. 25 - Jul. 1 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anhelina Kalinina | Win | |
| Second Round | Karolina Pliskova | Win | |
| Quarterfinals | Caroline Garcia | Win | |
| Semifinals | Camila Giorgi | Win | |
| Final | Madison Keys | Loss |
| Bett1 Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Elina Avanesyan | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 10 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Jule Niemeier | Win | |
| Second Round | Marketa Vondrousova | Win | |
| Third Round | Peyton Stearns | Win | |
| Fourth Round | Elina Svitolina | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 21 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lisa Pigato | Win | |
| Third Round | Julia Grabher | Win | |
| Fourth Round | Jelena Ostapenko | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 25 - May 6 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anastasia Pavlyuchenkova | Win | |
| Third Round | Lesia Tsurenko | Win | |
| Fourth Round | Veronika Kudermetova | Loss |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Paula Badosa | Loss |
| Credit One Charleston Open | ||
| Surface: Green Clay | Date: Apr. 3 - Apr. 9 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Madison Brengle | Win | |
| Third Round | Bernarda Pera | Win | |
| Quarterfinals | Madison Keys | Win | |
| Semifinals | Ons Jabeur | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 1 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Elise Mertens | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tatjana Maria | Win | |
| Third Round | Varvara Gracheva | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Barbora Krejcikova | Loss |
| Qatar Total Energies Open | ||
| Surface: Hard | Date: Feb. 13 - Feb. 18 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Rebecca Marino | Win | |
| Second Round | Beatriz Haddad Maia | Loss |
| Mubadala Abu Dhabi Open | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jil Teichmann | Win | |
| Quarterfinals | Qinwen Zheng | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Varvara Gracheva | Loss |
| Adelaide International 2 | ||
| Surface: Hard | Date: Jan. 9 - Jan. 14 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Barbora Krejcikova | Win | |
| Quarterfinals | Petra Kvitova | Win | |
| Semifinals | Paula Badosa | Win | |
| Final | Belinda Bencic | Loss |
| Adelaide International 1 | ||
| Surface: Hard | Date: Dec. 31 - Jan. 8 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Linda Noskova | Loss |
