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| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Vera Zvonareva | Win | 6-1, 7-6 (9-7) |
| Second Round | Clara Tauson | Win | 6-1, 7-5 |
| Third Round | Shelby Rogers | Loss | 2-6, 6-1, 6-7 (5-7) |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Heather Watson | Win | 6-4, 7-6 (7-3) |
| Third Round | Victoria Azarenka | Win | 6-0, 6-2 |
| Quarterfinals | Barbora Krejcikova | Win | 6-2, 6-4 |
| Semifinals | Angelique Kerber | Win | 6-2, 7-5 |
| Final | Jil Teichmann | Win | 6-3, 6-1 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Carla Suarez Navarro | Win | 6-1, 6-7 (1-7), 6-1 |
| Second Round | Anna Blinkova | Win | 6-4, 6-3 |
| Third Round | Katerina Siniakova | Win | 6-3, 7-5 |
| Fourth Round | Barbora Krejcikova | Win | 7-5, 6-3 |
| Quarterfinals | Ajla Tomljanovic | Win | 6-1, 6-3 |
| Semifinals | Angelique Kerber | Win | 6-3, 7-6 (7-3) |
| Final | Karolina Pliskova | Win | 6-3, 6-7 (4-7), 6-3 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bernarda Pera | Win | 6-4, 3-6, 6-2 |
| Second Round | Magda Linette | Loss | 1-6, 2-2 Retired |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yaroslava Shvedova | Win | 6-4, 6-1 |
| Third Round | Veronika Kudermetova | Win | 6-3, 6-3 |
| Quarterfinals | Cori Gauff | Loss | 6-4, 2-1 Retired |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Shelby Rogers | Win | 6-2, 6-1 |
| Second Round | Tamara Zidansek | Win | 6-4, 1-6, 6-3 |
| Third Round | Iga Swiatek | Win | 7-5, 6-4 |
| Quarterfinals | Petra Kvitova | Win | 6-1, 3-6, 6-3 |
| Semifinals | Paula Badosa | Win | 6-4, 6-3 |
| Final | Aryna Sabalenka | Loss | 0-6, 6-3, 4-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 19 - Apr. 25 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Laura Siegemund | Win | 6-0, 7-5 |
| Quarterfinals | Karolina Pliskova | Win | 2-6, 6-1, 7-5 |
| Semifinals | Elina Svitolina | Win | 4-6, 7-6 (7-5), 6-2 |
| Final | Aryna Sabalenka | Win | 3-6, 6-0, 6-3 |
| Volvo Car Open | ||
| Surface: Green Clay | Date: Apr. 5 - Apr. 11 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Misaki Doi | Win | 6-2, 6-1 |
| Third Round | Shelby Rogers | Win | 7-6 (7-3), 4-6, 6-4 |
| Quarterfinals | Paula Badosa | Loss | 4-6, 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kristina Kucova | Win | 6-3, 4-6, 7-5 |
| Third Round | Jelena Ostapenko | Win | 6-3, 6-2 |
| Fourth Round | Victoria Azarenka | Win | 6-1, 1-6, 6-2 |
| Quarterfinals | Aryna Sabalenka | Win | 6-4, 6-7 (5-7), 6-3 |
| Semifinals | Elina Svitolina | Win | 6-3, 6-3 |
| Final | Bianca Andreescu | Win | 6-3, 4-0 Retired |
| Adelaide International | ||
| Surface: Hard | Date: Feb. 22 - Feb. 27 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Danielle Collins | Loss | 3-6, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Danka Kovinic | Win | 6-0, 6-0 |
| Second Round | Daria Gavrilova | Win | 6-1, 7-6 (9-7) |
| Third Round | Ekaterina Alexandrova | Win | 6-2, 6-4 |
| Fourth Round | Shelby Rogers | Win | 6-3, 6-4 |
| Quarterfinals | Karolina Muchova | Loss | 6-1, 3-6, 2-6 |
| Yarra Valley Classic | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ana Bogdan | Win | 6-3, 6-3 |
| Third Round | Marie Bouzkova | Win | 6-0, 4-6, 6-3 |
| Quarterfinals | Shelby Rogers | Win | 7-5, 2-6, 10-4 |
| Semifinals | Serena Williams | Win | Retired |
| Final | Garbine Muguruza | Win | 7-6 (7-3), 6-4 |
