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| China Open | ||
| Surface: Hard | Date: Sep. 28 - Oct. 6 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yulia Putintseva | Win | 6-4, 6-2 |
| Third Round | Saisai Zheng | Win | 6-3, 6-7 (5-7), 6-2 |
| Quarterfinals | Petra Kvitova | Win | 4-6, 6-4, 6-3 |
| Semifinals | Kiki Bertens | Win | 6-3, 3-6, 7-6 (9-7) |
| Final | Naomi Osaka | Loss | 6-3, 3-6, 2-6 |
| Dongfeng Motor Wuhan Open | ||
| Surface: Hard | Date: Sep. 22 - Sep. 28 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Caroline Garcia | Win | 4-6, 6-4, 6-1 |
| Third Round | Sofia Kenin | Win | 6-3, 7-5 |
| Quarterfinals | Petra Martic | Win | 7-6 (8-6), 3-6, 6-3 |
| Semifinals | Aryna Sabalenka | Loss | 5-7, 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Zarina Diyas | Win | 1-6, 6-3, 6-2 |
| Second Round | Lauren Davis | Win | 6-2, 7-6 (7-2) |
| Third Round | Maria Sakkari | Win | 7-5, 6-3 |
| Fourth Round | Qiang Wang | Loss | 2-6, 4-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Maria Sharapova | Win | 6-4, 6-1 |
| Third Round | Anett Kontaveit | Win | 4-6, 7-5, 7-5 |
| Quarterfinals | Maria Sakkari | Win | 5-7, 6-2, 6-0 |
| Semifinals | Svetlana Kuznetsova | Loss | 2-6, 4-6 |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sofia Kenin | Loss | 7-6 (7-5), 3-6, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Saisai Zheng | Win | 6-4, 6-2 |
| Second Round | Alison Van Uytvanck | Win | 6-1, 6-3 |
| Third Round | Harriet Dart | Win | 6-1, 6-1 |
| Fourth Round | Alison Riske | Loss | 6-3, 2-6, 3-6 |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 17 - Jun. 23 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Donna Vekic | Win | 6-3, 6-4 |
| Second Round | Jennifer Brady | Win | 6-3, 6-1 |
| Quarterfinals | Venus Williams | Win | 6-4, 6-3 |
| Semifinals | Barbora Strycova | Win | 6-4, 6-4 |
| Final | Julia Goerges | Win | 6-3, 7-5 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Jessica Pegula | Win | 6-3, 6-3 |
| Second Round | Danielle Collins | Win | 7-5, 6-1 |
| Third Round | Andrea Petkovic | Win | 6-3, 6-1 |
| Fourth Round | Sofia Kenin | Win | 6-3, 3-6, 6-0 |
| Quarterfinals | Madison Keys | Win | 6-3, 7-5 |
| Semifinals | Amanda Anisimova | Win | 6-7 (4-7), 6-3, 6-3 |
| Final | Marketa Vondrousova | Win | 6-1, 6-3 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Viktoria Kuzmova | Win | 4-6, 6-3, 6-4 |
| Third Round | Kristina Mladenovic | Loss | 2-6, 3-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 4 - May 12 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Daria Gavrilova | Win | 6-1, 6-2 |
| Second Round | Danielle Collins | Win | 6-1, 1-6, 6-1 |
| Third Round | Yulia Putintseva | Win | 4-6, 6-1, 6-2 |
| Quarterfinals | Simona Halep | Loss | 5-7, 5-7 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dayana Yastremska | Win | 6-4, 6-1 |
| Third Round | Samantha Stosur | Win | 6-0, 6-3 |
| Fourth Round | Kiki Bertens | Win | 4-6, 6-3, 6-2 |
| Quarterfinals | Petra Kvitova | Win | 7-6 (8-6), 3-6, 6-2 |
| Semifinals | Anett Kontaveit | Win | 6-3, 6-3 |
| Final | Karolina Pliskova | Win | 7-6 (7-1), 6-3 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tatjana Maria | Win | 6-4, 6-4 |
| Third Round | Jennifer Brady | Win | 6-3, 6-2 |
| Fourth Round | Elina Svitolina | Loss | 6-7 (8-10), 7-5, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Luksika Kumkhum | Win | 6-2, 6-2 |
| Second Round | Yafan Wang | Win | 6-2, 6-3 |
| Third Round | Maria Sakkari | Win | 7-5, 6-1 |
| Fourth Round | Maria Sharapova | Win | 4-6, 6-1, 6-4 |
| Quarterfinals | Petra Kvitova | Loss | 1-6, 4-6 |
| Sydney International | ||
| Surface: Hard | Date: Jan. 6 - Jan. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jelena Ostapenko | Win | 6-3, 6-3 |
| Second Round | Simona Halep | Win | 6-4, 6-4 |
| Quarterfinals | Elise Mertens | Win | 6-3, 6-3 |
| Semifinals | Kiki Bertens | Win | 6-7 (4-7), 6-4, 7-5 |
| Final | Petra Kvitova | Loss | 6-1, 5-7, 6-7 (3-7) |
