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| China Open | ||
| Surface: Hard | Date: Sep. 30 - Oct. 8 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anna Blinkova |
| Toray Pan Pacific Open Tennis Tournament | ||
| Surface: Hard | Date: Sep. 25 - Oct. 1 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Cristina Bucsa | Win | 6-1, 6-2 |
| Quarterfinals | Daria Kasatkina | Win | 6-1, 6-0 |
| Semifinals | Maria Sakkari | Win | 6-2, 6-3 |
| Final | Veronika Kudermetova | Loss | 5-7, 1-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 9 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Camila Giorgi | Win | 6-2, 6-2 |
| Second Round | Patricia Maria Tig | Win | 6-3, 6-1 |
| Third Round | Elina Svitolina | Win | 6-4, 4-6, 6-2 |
| Fourth Round | Madison Keys | Loss | 1-6, 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 20 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Martina Trevisan | Win | 6-7 (2-7), 6-2, 6-3 |
| Third Round | Marie Bouzkova | Loss | 4-6, 0-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yulia Putintseva | Win | 6-4, 6-4 |
| Third Round | Jasmine Paolini | Win | 6-4, 6-0 |
| Quarterfinals | Coco Gauff | Win | 6-2, 5-7, 7-5 |
| Semifinals | Iga Swiatek | Win | 6-2, 6-7 (4-7), 6-4 |
| Final | Liudmila Samsonova | Win | 6-1, 6-0 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 15 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Lauren Davis | Win | |
| Second Round | Cristina Bucsa | Win | |
| Third Round | Elisabetta Cocciaretto | Win | |
| Fourth Round | Lesia Tsurenko | Win | |
| Quarterfinals | Marketa Vondrousova | Loss |
| Rothesay International Eastbourne | ||
| Surface: Grass | Date: Jun. 25 - Jul. 1 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Qinwen Zheng | Win | |
| Second Round | Camila Osorio | Win | |
| Quarterfinals | Coco Gauff | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 10 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Danielle Collins | Win | |
| Second Round | Camila Giorgi | Win | |
| Third Round | Elise Mertens | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 21 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Taylor Townsend | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 25 - May 6 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Magdalena Frech | Win | |
| Third Round | Marie Bouzkova | Win | |
| Fourth Round | Martina Trevisan | Win | |
| Quarterfinals | Veronika Kudermetova | Loss |
| Credit One Charleston Open | ||
| Surface: Green Clay | Date: Apr. 3 - Apr. 9 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anna Blinkova | Win | |
| Third Round | Irina-Camelia Begu | Win | |
| Quarterfinals | Paula Badosa | Win | |
| Semifinals | Belinda Bencic | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 1 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Katherine Sebov | Win | |
| Third Round | Danielle Collins | Win | |
| Fourth Round | Magda Linette | Win | |
| Quarterfinals | Anastasia Potapova | Win | |
| Semifinals | Elena Rybakina | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Camila Giorgi | Win | |
| Third Round | Anastasia Potapova | Win | |
| Fourth Round | Petra Kvitova | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Viktoriya Tomova | Win | |
| Third Round | Ana Bogdan | Win | |
| Quarterfinals | Karolina Muchova | Win | |
| Semifinals | Barbora Krejcikova | Loss |
| Qatar Total Energies Open | ||
| Surface: Hard | Date: Feb. 13 - Feb. 18 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jelena Ostapenko | Win | |
| Quarterfinals | Beatriz Haddad Maia | Win | |
| Semifinals | Maria Sakkari | Win | |
| Final | Iga Swiatek | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Jaqueline Cristian | Win | |
| Second Round | Aliaksandra Sasnovich | Win | |
| Third Round | Marta Kostyuk | Win | |
| Fourth Round | Barbora Krejcikova | Win | |
| Quarterfinals | Victoria Azarenka | Loss |
