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| Upper Austria Ladies Linz | ||
| Surface: Hard | Date: Nov. 7 - Nov. 12 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Mona Barthel | Win | 6-3, 6-1 |
| Second Round | Alize Cornet | Win | 6-4, 6-4 |
| Quarterfinals | Xinyu Wang | Win | 6-3, 7-5 |
| Semifinals | Danielle Collins | Win | 7-5, 0-0 Retired |
| Final | Jaqueline Cristian | Win | 2-6, 6-2, 7-5 |
| Courmayeur Ladies Open 2021 | ||
| Surface: Hard | Date: Oct. 25 - Oct. 31 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Ankita Raina | Win | 6-1, 6-1 |
| Second Round | Anna Kalinskaya | Loss | 3-6, 6-0, 3-6 |
| Tenerife Ladies Open | ||
| Surface: Hard | Date: Oct. 18 - Oct. 24 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Donna Vekic | Loss | 1-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | En-Shuo Liang | Win | 6-2, 6-2 |
| Second Round | Bianca Andreescu | Loss | 6-7 (2-7), 7-5, 2-6 |
| J&T Banka Ostrava Open 2021 | ||
| Surface: Hard | Date: Sep. 20 - Sep. 26 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Fiona Ferro | Win | 6-4, 1-6, 6-4 |
| Second Round | Jil Teichmann | Loss | 3-6, 6-1, 4-6 |
| Zavarovalnica Sava Portoroz | ||
| Surface: Hard | Date: Sep. 13 - Sep. 19 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Pia Lovric | Win | 7-5, 6-3 |
| Second Round | Viktoria Kuzmova | Win | 3-6, 6-3, 6-3 |
| Quarterfinals | Kristina Mladenovic | Win | 6-4, 6-1 |
| Semifinals | Kaja Juvan | Win | 6-0, 6-4 |
| Final | Jasmine Paolini | Loss | 6-7 (4-7), 2-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Pavlyuchenkova | Loss | 4-6, 2-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Leylah Fernandez | Win | 6-2, 6-2 |
| Second Round | Victoria Azarenka | Loss | 2-6, 5-7 |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Sorana Cirstea | Loss | 3-6, 4-6 |
| Mubadala Silicon Valley Classic | ||
| Surface: Hard | Date: Aug. 2 - Aug. 8 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Coco Vandeweghe | Win | 6-3, 6-4 |
| Second Round | Ana Konjuh | Loss | 1-6, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 28 |
| Round | Opponent | W / L | Result |
| First Round | Tereza Martincova | Loss | 2-6, 6-4, 1-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 21 - Jun. 26 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Veronika Kudermetova | Win | 6-3, 6-4 |
| Second Round | Aryna Sabalenka | Loss | 1-6, 4-6 |
| Nature Valley Open | ||
| Surface: Grass | Date: Jun. 7 - Jun. 13 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Xiyu Wang | Win | 3-6, 7-5, 7-6 (7-3) |
| Third Round | Lauren Davis | Loss | 7-6 (7-3), 4-6, 4-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Iga Swiatek | Loss | 4-5 Retired |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Iga Swiatek | Loss | 1-6, 1-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 24 |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Potapova | Loss | 2-6, 1-6 |
