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| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: Sep. 14 - Sep. 21 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Barbora Strycova | Win | 6-3, 6-3 |
| Third Round | Anna Blinkova | Win | 6-4, 6-3 |
| Quarterfinals | Elise Mertens | Win | 6-3, 3-6, 6-0 |
| Semifinals | Marketa Vondrousova |
| US Open | ||
| Surface: Hard | Date: Aug. 31 - Sep. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Anhelina Kalinina | Win | 6-4, 6-0 |
| Second Round | Caroline Garcia | Loss | 1-6, 6-7 (2-7) |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 22 - Aug. 29 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Veronika Kudermetova | Loss | 5-7, 4-6 |
| Qatar Total Open 2020 | ||
| Surface: Hard | Date: Feb. 23 - Feb. 29 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Bernarda Pera | Win | 6-3, 6-0 |
| Third Round | Ons Jabeur | Loss | 4-6, 6-3, 3-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 17 - Feb. 22 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kristina Mladenovic | Win | 6-1, 6-2 |
| Quarterfinals | Elena Rybakina | Loss | 6-7 (1-7), 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 20 - Feb. 2 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Kristina Mladenovic | Win | 6-1, 7-5 |
| Second Round | Laura Siegemund | Win | 6-3, 6-3 |
| Third Round | Anastasia Pavlyuchenkova | Loss | 6-7 (4-7), 6-7 (3-7) |
| Brisbane International | ||
| Surface: Hard | Date: Jan. 6 - Jan. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ajla Tomljanovic | Win | 6-4, 6-7 (5-7), 6-1 |
| Quarterfinals | Alison Riske | Win | 7-6 (8-6), 6-3 |
| Semifinals | Naomi Osaka | Win | 6-7 (10-12), 7-6 (7-3), 6-2 |
| Final | Madison Keys | Win | 6-4, 4-6, 7-5 |
