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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Attila Balazs | Win | 6-1, 6-1, 6-0 |
| Second Round | Christopher O'Connell | Win | 6-2, 6-2, 6-7 (6-8), 6-2 |
| Third Round | Sebastian Baez | Win | 6-2, 6-2, 7-6 (8-6) |
| Fourth Round | Alex De Minaur | Win | 2-6, 6-4, 6-1, 6-2 |
| Quarterfinals | Andrey Rublev | Win | 6-4, 6-3, 6-4 |
| Semifinals | Carlos Alcaraz | Win | 7-6 (7-3), 6-1, 3-6, 6-3 |
| Final | Novak Djokovic | Loss | 3-6, 6-7 (5-7), 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lorenzo Musetti | Win | 6-3, 6-2 |
| Third Round | Alexander Zverev | Loss | 4-6, 7-5, 4-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Matteo Arnaldi | Win | 6-2, 7-5 |
| Third Round | Lorenzo Musetti | Win | 6-4, 6-4 |
| Quarterfinals | Alex De Minaur | Loss | 6-7 (7-9), 5-7 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Arthur Fery | Win | |
| Second Round | Adrian Mannarino | Win | |
| Third Round | Marton Fucsovics | Win | |
| Fourth Round | Jiri Lehecka | Win | |
| Quarterfinals | Christopher Eubanks | Win | |
| Semifinals | Carlos Alcaraz | Loss |
| Terra Wortmann Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Marcos Giron | Win | |
| Second Round | Laslo Djere | Win | |
| Quarterfinals | Roberto Bautista Agut | Loss |
| Libema Open | ||
| Surface: Grass | Date: Jun. 12 - Jun. 18 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Adrian Mannarino | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Thiago Seyboth Wild | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Emil Ruusuvuori | Win | |
| Third Round | Bernabe Zapata Miralles | Win | |
| Fourth Round | Alexander Zverev | Win | |
| Quarterfinals | Yannick Hanfmann | Win | |
| Semifinals | Stefanos Tsitsipas | Win | |
| Final | Holger Rune | Win |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Andrea Vavassori | Win | |
| Third Round | Alexander Shevchenko | Win | |
| Fourth Round | Aslan Karatsev | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lorenzo Sonego | Win | |
| Third Round | Alexander Zverev | Win | |
| Quarterfinals | Holger Rune | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Roberto Carballes Baena | Win | |
| Third Round | Alex Molcan | Win | |
| Fourth Round | Quentin Halys | Win | |
| Quarterfinals | Christopher Eubanks | Win | |
| Semifinals | Karen Khachanov | Win | |
| Final | Jannik Sinner | Win |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Brandon Nakashima | Win | |
| Third Round | Ilya Ivashka | Win | |
| Fourth Round | Alexander Zverev | Win | |
| Quarterfinals | Alejandro Davidovich Fokina | Win | |
| Semifinals | Frances Tiafoe | Win | |
| Final | Carlos Alcaraz | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 27 - Mar. 4 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Matteo Arnaldi | Win | |
| Second Round | Alexander Bublik | Win | |
| Quarterfinals | Borna Coric | Win | |
| Semifinals | Novak Djokovic | Win | |
| Final | Andrey Rublev | Win |
| Qatar ExxonMobil Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 25 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Liam Broady | Win | |
| Quarterfinals | Christopher O'Connell | Win | |
| Semifinals | Felix Auger-Aliassime | Win | |
| Final | Andy Murray | Win |
| ABN Amro World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Alejandro Davidovich Fokina | Win | |
| Second Round | Botic Van De Zandschulp | Win | |
| Quarterfinals | Felix Auger-Aliassime | Win | |
| Semifinals | Grigor Dimitrov | Win | |
| Final | Jannik Sinner | Win |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Marcos Giron | Win | |
| Second Round | John Millman | Win | |
| Third Round | Sebastian Korda | Loss |
| Adelaide International 1 | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Lorenzo Sonego | Win | |
| Second Round | Miomir Kecmanovic | Win | |
| Quarterfinals | Karen Khachanov | Win | |
| Semifinals | Novak Djokovic | Loss |
