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| Rolex Paris Masters | ||
| Surface: Hard | Date: Oct. 30 - Nov. 5 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Richard Gasquet | Win | 0-6, 6-2, 7-6 (8-6) |
| Second Round | Botic Van De Zandschulp | Loss | 4-6, 6-2, 3-6 |
| Erste Bank Open | ||
| Surface: Hard | Date: Oct. 23 - Oct. 29 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Alexandre Muller | Win | 6-3, 6-1 |
| Second Round | Borna Gojo | Loss | 3-6, 4-6 |
| Rakuten Japan Open Tennis Championships | ||
| Surface: Hard | Date: Oct. 15 - Oct. 22 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Daniel Altmaier | Win | 3-6, 6-1, 6-3 |
| Second Round | Mackenzie McDonald | Win | 6-4, 6-2 |
| Quarterfinals | Ben Shelton | Loss | 6-7 (4-7), 3-6 |
| Rolex Shanghai Masters | ||
| Surface: Hard | Date: Oct. 4 - Oct. 15 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sebastian Ofner | Win | 6-3, 6-0 |
| Third Round | Arthur Fils | Win | 6-4, 6-7 (7-9), 6-4 |
| Fourth Round | Andrey Rublev | Loss | 5-7, 5-7 |
| China Open | ||
| Surface: Hard | Date: Sep. 28 - Oct. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Daniil Medvedev | Loss | 2-6, 1-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Stefano Travaglia | Win | |
| Second Round | Roman Safiullin | Win | |
| Third Round | Alejandro Davidovich Fokina | Win | |
| Fourth Round | Ben Shelton | Loss |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Miomir Kecmanovic | Win | |
| Second Round | Ugo Humbert | Win | |
| Third Round | Carlos Alcaraz | Loss |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Diego Schwartzman | Win | |
| Second Round | Francisco Cerundolo | Win | |
| Third Round | Marcos Giron | Win | |
| Quarterfinals | Carlos Alcaraz | Win | |
| Semifinals | Jannik Sinner | Loss |
| Abierto de Tenis Mifel | ||
| Surface: Hard | Date: Aug. 1 - Aug. 6 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Felipe Meligeni Alves | Win | |
| Quarterfinals | Alex De Minaur | Loss |
| Infosys Hall of Fame Open | ||
| Surface: Grass | Date: Jul. 17 - Jul. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ethan Quinn | Win | |
| Quarterfinals | John Isner | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Shintaro Mochizuki | Win | |
| Second Round | Milos Raonic | Win | |
| Third Round | Jiri Lehecka | Loss |
| Rothesay International Eastbourne | ||
| Surface: Grass | Date: Jun. 26 - Jul. 1 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sebastian Baez | Win | |
| Quarterfinals | J.J. Wolf | Win | |
| Semifinals | Gregoire Barrere | Win | |
| Final | Francisco Cerundolo | Loss |
| Cinch Championships | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Francisco Cerundolo | Loss |
| Boss Open | ||
| Surface: Grass | Date: Jun. 12 - Jun. 18 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Benjamin Bonzi | Win | |
| Second Round | Jan-Lennard Struff | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Dominic Stricker | Win | |
| Second Round | Nicolas Jarry | Loss |
| Open Parc Auvergne-Rhone-Alpes Lyon | ||
| Surface: Clay | Date: May 21 - May 27 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gregoire Barrere | Win | |
| Quarterfinals | Brandon Nakashima | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Cristian Garin | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Roman Safiullin | Loss |
| Fayez Sarofim & Co. U.S. Men's Clay Court Championship | ||
| Surface: Clay | Date: Apr. 3 - Apr. 9 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yannick Hanfmann | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marc-Andrea Huesler | Win | |
| Third Round | Alejandro Davidovich Fokina | Win | |
| Fourth Round | Carlos Alcaraz | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jan-Lennard Struff | Win | |
| Third Round | Hubert Hurkacz | Win | |
| Fourth Round | Felix Auger-Aliassime | Loss |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Feb. 26 - Mar. 4 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Emilio Gomez | Win | |
| Second Round | Michael Mmoh | Win | |
| Quarterfinals | Mackenzie McDonald | Win | |
| Semifinals | Taylor Fritz | Win | |
| Final | Alex De Minaur | Loss |
| Delray Beach Open | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Denis Kudla | Win | |
| Quarterfinals | Radu Albot | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jan-Lennard Struff | Win | |
| Second Round | Alejandro Davidovich Fokina | Win | |
| Third Round | Jenson Brooksby | Win | |
| Fourth Round | Roberto Bautista Agut | Win | |
| Quarterfinals | Ben Shelton | Win | |
| Semifinals | Novak Djokovic | Loss |
| Adelaide International 2 | ||
| Surface: Hard | Date: Jan. 9 - Jan. 14 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Christopher O'Connell | Win | |
| Second Round | Jack Draper | Loss |
