| ||||||||||||||
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Learner Tien | Win | 6-2, 7-5, 6-1 |
| Second Round | Sebastian Ofner | Win | 6-3, 6-1, 6-4 |
| Third Round | Adrian Mannarino | Win | 4-6, 6-2, 6-3, 7-6(8-6) |
| Fourth Round | Rinky Hijikata | Win | 6-4, 6-1, 6-4 |
| Quarterfinals | Ben Shelton | Loss | 2-6, 6-3, 6-7 (7-9), 2-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Tallon Griekspoor | Win | 6-4, 6-7 (7-9), 6-4 |
| Second Round | Stan Wawrinka | Loss | 3-6, 4-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Milos Raonic | Loss | 7-6 (14-12), 6-7 (4-7), 3-6 |
| Citi Open | ||
| Surface: Hard | Date: Jul. 31 - Aug. 6 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aslan Karatsev | Win | 7-6 (7-5), 7-6 (7-5) |
| Third Round | Juncheng Shang | Win | 6-2, 6-3 |
| Quarterfinals | Daniel Evans | Loss | 4-6, 5-7 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Yibing Wu | Win | |
| Second Round | Dominic Stricker | Win | |
| Third Round | Grigor Dimitrov | Loss |
| Cinch Championships | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Botic Van De Zandschulp | Win | |
| Second Round | Sebastian Korda | Loss |
| Boss Open | ||
| Surface: Grass | Date: Jun. 12 - Jun. 18 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jiri Lehecka | Win | |
| Quarterfinals | Lorenzo Musetti | Win | |
| Semifinals | Marton Fucsovics | Win | |
| Final | Jan-Lennard Struff | Win |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Filip Krajinovic | Win | |
| Second Round | Aslan Karatsev | Win | |
| Third Round | Alexander Zverev | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daniel Altmaier | Win | |
| Third Round | Lorenzo Musetti | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tomas Martin Etcheverry | Win | |
| Third Round | Pedro Cachin | Loss |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Emil Ruusuvuori | Loss |
| Fayez Sarofim & Co. U.S. Men's Clay Court Championship | ||
| Surface: Clay | Date: Apr. 3 - Apr. 9 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Steve Johnson | Win | |
| Quarterfinals | Jason Kubler | Win | |
| Semifinals | Gijs Brouwer | Win | |
| Final | Tomas Martin Etcheverry | Win |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yosuke Watanuki | Win | |
| Third Round | Lorenzo Sonego | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marcos Giron | Win | |
| Third Round | Jason Kubler | Win | |
| Fourth Round | Alejandro Tabilo | Win | |
| Quarterfinals | Cameron Norrie | Win | |
| Semifinals | Daniil Medvedev | Loss |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Feb. 26 - Mar. 4 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Yoshihito Nishioka | Win | |
| Second Round | Feliciano Lopez | Win | |
| Quarterfinals | Taylor Fritz | Loss |
| Dallas Open | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mackenzie McDonald | Win | |
| Quarterfinals | J.J. Wolf | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Daniel Altmaier | Win | |
| Second Round | Juncheng Shang | Win | |
| Third Round | Karen Khachanov | Loss |
