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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Yannick Hanfmann | Win | 6-3, 6-1, 6-1 |
| Second Round | Lorenzo Sonego | Win | 6-4, 6-2, 6-4 |
| Third Round | Stan Wawrinka | Win | 6-3, 2-6, 6-4, 6-2 |
| Fourth Round | Alexander Zverev | Loss | 4-6, 6-3, 2-6, 6-4, 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dusan Lajovic | Loss | 4-6, 6-7 (4-7) |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Matteo Berrettini | Win | 6-4, 6-3 |
| Third Round | Andy Murray | Win | Retired |
| Quarterfinals | Gael Monfils | Win | 6-4, 4-6, 6-3 |
| Semifinals | Tommy Paul | Win | 6-4, 6-4 |
| Final | Alex De Minaur | Win | 6-4, 6-1 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Juan Manuel Cerundolo | Win | |
| Second Round | Diego Schwartzman | Win | |
| Third Round | Quentin Halys | Win | |
| Fourth Round | Daniel Elahi Galan | Win | |
| Quarterfinals | Roman Safiullin | Win | |
| Semifinals | Novak Djokovic | Loss |
| Terra Wortmann Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Richard Gasquet | Win | |
| Second Round | Lorenzo Sonego | Win | |
| Quarterfinals | Alexander Bublik | Loss |
| Libema Open | ||
| Surface: Grass | Date: Jun. 12 - Jun. 18 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexander Bublik | Win | |
| Quarterfinals | Emil Ruusuvuori | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Alexandre Muller | Win | |
| Second Round | Daniel Altmaier | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Thanasi Kokkinakis | Win | |
| Third Round | Alexander Shevchenko | Win | |
| Fourth Round | Francisco Cerundolo | Loss |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Diego Schwartzman | Win | |
| Third Round | Yoshihito Nishioka | Win | |
| Quarterfinals | Lorenzo Musetti | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Diego Schwartzman | Win | |
| Third Round | Hubert Hurkacz | Win | |
| Quarterfinals | Lorenzo Musetti | Win | |
| Semifinals | Holger Rune | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Laslo Djere | Win | |
| Third Round | Grigor Dimitrov | Win | |
| Fourth Round | Andrey Rublev | Win | |
| Quarterfinals | Emil Ruusuvuori | Win | |
| Semifinals | Carlos Alcaraz | Win | |
| Final | Daniil Medvedev | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Richard Gasquet | Win | |
| Third Round | Adrian Mannarino | Win | |
| Fourth Round | Stan Wawrinka | Win | |
| Quarterfinals | Taylor Fritz | Win | |
| Semifinals | Carlos Alcaraz | Loss |
| Open 13 Provence | ||
| Surface: Hard | Date: Feb. 20 - Feb. 26 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Arthur Fils | Loss |
| ABN Amro World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Benjamin Bonzi | Win | |
| Second Round | Stefanos Tsitsipas | Win | |
| Quarterfinals | Stan Wawrinka | Win | |
| Semifinals | Tallon Griekspoor | Win | |
| Final | Daniil Medvedev | Loss |
| Open Sud de France | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marton Fucsovics | Win | |
| Quarterfinals | Lorenzo Sonego | Win | |
| Semifinals | Arthur Fils | Win | |
| Final | Maxime Cressy | Win |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Kyle Edmund | Win | |
| Second Round | Tomas Martin Etcheverry | Win | |
| Third Round | Marton Fucsovics | Win | |
| Fourth Round | Stefanos Tsitsipas | Loss |
| Adelaide International 1 | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Kyle Edmund | Win | |
| Second Round | Thanasi Kokkinakis | Win | |
| Quarterfinals | Sebastian Korda | Loss |
