| Saturday, 2 October 2021 |
| Time/Result | Home | Away | Venue |
| 2-1 |
Austin |
Real Salt Lake | Q2 Stadium |
| 2-1 |
CF Montreal |
Atlanta | Stade Saputo |
| 2-1 |
Orlando City SC |
D.C. | Exploria Stadium |
| 0-1 |
FC Cincinnati |
New York | TQL Stadium |
| 0-0 |
FC Dallas |
Minnesota | Toyota Stadium |
| 3-0 |
Vancouver |
San Jose | BC Place Stadium |
| Sunday, 3 October 2021 |
| Time/Result | Home | Away | Venue |
| 0-0 |
New York City FC |
Nashville SC | Red Bull Arena |
| 4-2 |
Sporting KC |
Houston | Children's Mercy Park |
| 3-1 |
Toronto FC |
Chicago | BMO Field |
| 3-0 |
Philadelphia |
Columbus | Talen Energy Stadium |
| 1-0 |
Portland |
Inter Miami CF | Providence Park |
| 1-1 |
Los Angeles |
Los Angeles FC | Dignity Health Sports Park |
| 3-0 |
Seattle |
Colorado | CenturyLink Field |
| Saturday, 9 October 2021 |
| Time/Result | Home | Away | Venue |
| 1-0 |
New York |
Inter Miami CF | Red Bull Arena |
| 1-2 |
FC Cincinnati |
Philadelphia | TQL Stadium |
| 4-1 |
Seattle |
Vancouver | CenturyLink Field |
| Sunday, 10 October 2021 |
| Time/Result | Home | Away | Venue |
| 1-3 |
Minnesota |
Colorado | Allianz Field |
| Saturday, 16 October 2021 |
| Time/Result | Home | Away | Venue |
| 2-2 |
CF Montreal |
Philadelphia | Stade Saputo |
| 3-1 |
Los Angeles FC |
San Jose | Banc of California Stadium |
| 4-0 |
Columbus |
Inter Miami CF | Lower.com Field |
| 2-2 |
New England |
Chicago | Gillette Stadium |
| 0-0 |
D.C. |
Nashville SC | Audi Field |
| 0-2 |
Toronto FC |
Atlanta | BMO Field |
| 0-1 |
FC Cincinnati |
Orlando City SC | TQL Stadium |
| 2-1 |
Houston |
Seattle | BBVA Stadium |
| 0-1 |
Austin |
Minnesota | Q2 Stadium |
| 3-1 |
Real Salt Lake |
Colorado | Rio Tinto Stadium |
| 2-1 |
Los Angeles |
Portland | Dignity Health Sports Park |
| Sunday, 17 October 2021 |
| Time/Result | Home | Away | Venue |
| 1-0 |
New York |
New York City FC | Red Bull Arena |
| 2-1 |
Vancouver |
Sporting KC | BC Place Stadium |
| Wednesday, 20 October 2021 |
| Time/Result | Home | Away | Venue |
| 2-3 |
D.C. |
New England | Audi Field |
| 1-1 |
Orlando City SC |
CF Montreal | Exploria Stadium |
| 3-4 |
FC Cincinnati |
Chicago | TQL Stadium |
| 1-1 |
Atlanta |
New York City FC | Mercedes-Benz Stadium |
| 3-0 |
Inter Miami CF |
Toronto FC | Inter Miami CF Stadium |
| 2-3 |
FC Dallas |
Los Angeles FC | Toyota Stadium |
| 3-2 |
Minnesota |
Philadelphia | Allianz Field |
| 0-3 |
Houston |
Los Angeles | BBVA Stadium |
| 1-1 |
Nashville SC |
Columbus | Nissan Stadium |
| 1-1 |
Colorado |
Seattle | Dick's Sporting Goods Park |
| 2-3 |
Portland |
Vancouver | Providence Park |
| 4-0 |
San Jose |
Austin | Earthquakes Stadium |
| Saturday, 23 October 2021 |
| Time/Result | Home | Away | Venue |
| 1-2 |
Seattle |
Sporting KC | CenturyLink Field |
| 1-2 |
Columbus |
New York | Lower.com Field |
| 1-1 |
Toronto FC |
CF Montreal | BMO Field |
| 1-0 |
Philadelphia |
Nashville SC | Talen Energy Stadium |
| 6-0 |
New York City FC |
D.C. | Yankee Stadium |
| 1-0 |
Chicago |
Real Salt Lake | Soldier Field |
| 1-1 |
Minnesota |
Los Angeles FC | Allianz Field |
| 5-1 |
Inter Miami CF |
FC Cincinnati | Inter Miami CF Stadium |
| 2-0 |
Colorado |
Portland | Dick's Sporting Goods Park |
| 2-2 |
Los Angeles |
FC Dallas | Dignity Health Sports Park |
| 1-1 |
San Jose |
Vancouver | Earthquakes Stadium |
| Sunday, 24 October 2021 |
| Time/Result | Home | Away | Venue |
| 2-1 |
Austin |
Houston | Q2 Stadium |
| 2-2 |
Orlando City SC |
New England | Exploria Stadium |
| Tuesday, 26 October 2021 |
| Time/Result | Home | Away | Venue |
| 3-0 |
Los Angeles FC |
Seattle | Banc of California Stadium |
| Wednesday, 27 October 2021 |
| Time/Result | Home | Away | Venue |
| 1-0 |
New England |
Colorado | Gillette Stadium |
| 3-2 |
Columbus |
Orlando City SC | Lower.com Field |
| 1-0 |
D.C. |
New York | Audi Field |
| 2-2 |
Toronto FC |
Philadelphia | BMO Field |
| 1-0 |
New York City FC |
Chicago | Yankee Stadium |
| 3-6 |
FC Cincinnati |
Nashville SC | TQL Stadium |
| 2-1 |
Atlanta |
Inter Miami CF | Mercedes-Benz Stadium |
| 1-2 |
FC Dallas |
Real Salt Lake | Toyota Stadium |
| 2-0 |
Sporting KC |
Los Angeles | Children's Mercy Park |
| 2-1 |
Vancouver |
Minnesota | BC Place Stadium |
| 2-0 |
Portland |
San Jose | Providence Park |
| Saturday, 30 October 2021 |
| Time/Result | Home | Away | Venue |
| 10:30 AM PT11:30 AM MT12:30 PM CT1:30 PM ET17:30 GMT18:30 17:30 5:30 PM 19:30 KSA4:30 AM AET23:00 IST1:00 PM VEN21:30 UAE1:30 AM SST1:30 0:30 10:30 AM MST11:30 AM CST12:30 PM EST13:30 ET12:30 14:30 BRT13:30 12:30 PM CT |
Inter Miami CF |
New York City FC | Inter Miami CF Stadium |
| 12:30 PM PT1:30 PM MT2:30 PM CT3:30 PM ET19:30 GMT20:30 19:30 7:30 PM 21:30 KSA6:30 AM AET1:00 (+1) IST3:00 PM VEN23:30 UAE3:30 AM SST3:30 2:30 12:30 PM MST1:30 PM CST2:30 PM EST15:30 ET14:30 16:30 BRT15:30 2:30 PM CT |
Real Salt Lake |
San Jose | Rio Tinto Stadium |
| 1:00 PM PT2:00 PM MT3:00 PM CT4:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST16:00 ET15:00 17:00 BRT16:00 3:00 PM CT |
New York |
CF Montreal | Red Bull Arena |
| 3:00 PM PT4:00 PM MT5:00 PM CT6:00 PM ET22:00 GMT23:00 22:00 10:00 PM 0:00 KSA9:00 AM AET3:30 (+1) IST5:30 PM VEN2:00 (+1) UAE6:00 AM SST6:00 5:00 3:00 PM MST4:00 PM CST5:00 PM EST18:00 ET17:00 19:00 BRT18:00 5:00 PM CT |
Atlanta |
Toronto FC | Mercedes-Benz Stadium |
| 4:30 PM PT5:30 PM MT6:30 PM CT7:30 PM ET23:30 GMT0:30 23:30 11:30 PM 1:30 KSA10:30 AM AET5:00 (+1) IST7:00 PM VEN3:30 (+1) UAE7:30 AM SST7:30 6:30 4:30 PM MST5:30 PM CST6:30 PM EST19:30 ET18:30 20:30 BRT19:30 6:30 PM CT |
D.C. |
Columbus | Audi Field |
| 6:00 PM PT7:00 PM MT8:00 PM CT9:00 PM ET1:00 (+1) GMT2:00 1:00 1:00 AM 3:00 KSA12:00 AM AET6:30 (+1) IST8:30 PM VEN5:00 (+1) UAE9:00 AM SST9:00 8:00 6:00 PM MST7:00 PM CST8:00 PM EST21:00 ET20:00 22:00 BRT21:00 8:00 PM CT |
FC Dallas |
Austin | Toyota Stadium |
| Sunday, 31 October 2021 |
| Time/Result | Home | Away | Venue |
| 10:00 AM PT11:00 AM MT12:00 PM CT1:00 PM ET17:00 GMT18:00 17:00 5:00 PM 19:00 KSA4:00 AM AET22:30 IST12:30 PM VEN21:00 UAE1:00 AM SST1:00 0:00 10:00 AM MST11:00 AM CST12:00 PM EST13:00 ET12:00 14:00 BRT13:00 12:00 PM CT |
Minnesota |
Sporting KC | Allianz Field |
| 12:30 PM PT1:30 PM MT2:30 PM CT3:30 PM ET19:30 GMT20:30 19:30 7:30 PM 21:30 KSA6:30 AM AET1:00 (+1) IST3:00 PM VEN23:30 UAE3:30 AM SST3:30 2:30 12:30 PM MST1:30 PM CST2:30 PM EST15:30 ET14:30 16:30 BRT15:30 2:30 PM CT |
Houston |
Colorado | BBVA Stadium |
| 1:00 PM PT2:00 PM MT3:00 PM CT4:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST16:00 ET15:00 17:00 BRT16:00 3:00 PM CT |
Orlando City SC |
Nashville SC | Exploria Stadium |
| 4:30 PM PT5:30 PM MT6:30 PM CT7:30 PM ET23:30 GMT0:30 23:30 11:30 PM 1:30 KSA10:30 AM AET5:00 (+1) IST7:00 PM VEN3:30 (+1) UAE7:30 AM SST7:30 6:30 4:30 PM MST5:30 PM CST6:30 PM EST19:30 ET18:30 20:30 BRT19:30 6:30 PM CT |
Philadelphia |
FC Cincinnati | Talen Energy Stadium |
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