2010 NCAA Football Big 12 Conference Schedule
| | Baylor Bears | | Sep 4 - W vs. Sam Houston St, 34-3 | | Sep 11 - W vs. Buffalo, 34-6 | | Sep 18 - L at TCU, 10-45 | | Sep 25 - W at Rice, 30-13 | | Oct 2 - W vs. Kansas, 55-7 | | Oct 9 - L at Texas Tech, 38-45 | | Oct 16 - W at Colorado, 31-25 | | Oct 23 - W vs. Kansas State, 47-42 | | Oct 30 - W at Texas, 30-22 | | Nov 6 - L at Oklahoma State, 28-55 | | Nov 13 - L vs. Texas A&M, 30-42 | | Nov 20 - L vs. Oklahoma, 24-53 | | Nov 27 - Open | | Dec 4 - Open | | Dec 11 - Open | | Dec 29 - L vs. Illinois, 14-38 |
| | Iowa State Cyclones | | Sep 2 - W vs. Northern Ill, 27-10 | | Sep 11 - L at Iowa, 7-35 | | Sep 18 - L at Kansas State, 20-27 | | Sep 25 - W vs. Northern Iowa, 27-0 | | Oct 2 - W vs. Texas Tech, 52-38 | | Oct 9 - L vs. Utah, 27-68 | | Oct 16 - L at Oklahoma, 0-52 | | Oct 23 - W at Texas, 28-21 | | Oct 30 - W vs. Kansas, 28-16 | | Nov 6 - L vs. Nebraska, 30-31 OT | | Nov 13 - L at Colorado, 14-34 | | Nov 20 - L vs. Missouri, 0-14 |
| | Kansas Jayhawks | | Sep 4 - L vs. North Dakota St, 3-6 | | Sep 11 - W vs. Georgia Tech, 28-25 | | Sep 17 - L at Southern Miss, 16-31 | | Sep 25 - W vs. New Mexico St, 42-16 | | Oct 2 - L at Baylor, 7-55 | | Oct 9 - Open | | Oct 14 - L vs. Kansas State, 7-59 | | Oct 23 - L vs. Texas A&M, 10-45 | | Oct 30 - L at Iowa State, 16-28 | | Nov 6 - W vs. Colorado, 52-45 | | Nov 13 - L at Nebraska, 3-20 | | Nov 20 - L vs. Oklahoma State, 14-48 | | Nov 27 - L at Missouri, 7-35 |
| | Kansas State Wildcats | | Sep 4 - W vs. UCLA, 31-22 | | Sep 11 - W vs. Missouri State, 48-24 | | Sep 18 - W vs. Iowa State, 27-20 | | Sep 25 - W vs. UCF, 17-13 | | Oct 2 - Open | | Oct 7 - L vs. Nebraska, 13-48 | | Oct 14 - W at Kansas, 59-7 | | Oct 23 - L at Baylor, 42-47 | | Oct 30 - L vs. Oklahoma State, 14-24 | | Nov 6 - W vs. Texas, 39-14 | | Nov 13 - L at Missouri, 28-38 | | Nov 20 - L at Colorado, 36-44 | | Nov 27 - W at North Texas, 49-41 | | Dec 4 - Open | | Dec 11 - Open | | Dec 30 - L at Syracuse, 34-36 |
| | Oklahoma Sooners | | Sep 4 - W vs. Utah State, 31-24 | | Sep 11 - W vs. Florida State, 47-17 | | Sep 18 - W vs. Air Force, 27-24 | | Sep 25 - W at Cincinnati, 31-29 | | Oct 2 - W vs. Texas, 28-20 | | Oct 9 - Open | | Oct 16 - W vs. Iowa State, 52-0 | | Oct 23 - L at Missouri, 27-36 | | Oct 30 - W vs. Colorado, 43-10 | | Nov 6 - L at Texas A&M, 19-33 | | Nov 13 - W vs. Texas Tech, 45-7 | | Nov 20 - W at Baylor, 53-24 | | Nov 27 - W at Oklahoma State, 47-41 | | Dec 4 - W vs. Nebraska, 23-20 | | Dec 11 - Open | | Jan 1 - W vs. Connecticut, 48-20 |
| | Oklahoma State Cowboys | | Sep 4 - W vs. Washington St, 65-17 | | Sep 11 - W vs. Troy, 41-38 | | Sep 18 - W vs. Tulsa, 65-28 | | Sep 25 - Open | | Sep 30 - W vs. Texas A&M, 38-35 | | Oct 8 - W at Louisiana, 54-28 | | Oct 16 - W at Texas Tech, 34-17 | | Oct 23 - L vs. Nebraska, 41-51 | | Oct 30 - W at Kansas State, 24-14 | | Nov 6 - W vs. Baylor, 55-28 | | Nov 13 - W at Texas, 33-16 | | Nov 20 - W at Kansas, 48-14 | | Nov 27 - L vs. Oklahoma, 41-47 | | Dec 4 - Open | | Dec 11 - Open | | Dec 29 - W at Arizona, 36-10 |
| | TCU Horned Frogs | | Sep 4 - W vs. Oregon State, 30-21 | | Sep 11 - W vs. Tenn Tech, 62-7 | | Sep 18 - W vs. Baylor, 45-10 | | Sep 24 - W at SMU, 41-24 | | Oct 2 - W at Colorado State, 27-0 | | Oct 9 - W vs. Wyoming, 45-0 | | Oct 16 - W vs. BYU, 31-3 | | Oct 23 - W vs. Air Force, 38-7 | | Oct 30 - W at UNLV, 48-6 | | Nov 6 - W at Utah, 47-7 | | Nov 13 - W vs. San Diego St, 40-35 | | Nov 20 - Open | | Nov 27 - W at New Mexico, 66-17 | | Dec 4 - Open | | Dec 11 - Open | | Jan 1 - W vs. Wisconsin, 21-19 |
| | Texas Longhorns | | Sep 4 - W at Rice, 34-17 | | Sep 11 - W vs. Wyoming, 34-7 | | Sep 18 - W at Texas Tech, 24-14 | | Sep 25 - L vs. UCLA, 12-34 | | Oct 2 - L at Oklahoma, 20-28 | | Oct 9 - Open | | Oct 16 - W at Nebraska, 20-13 | | Oct 23 - L vs. Iowa State, 21-28 | | Oct 30 - L vs. Baylor, 22-30 | | Nov 6 - L at Kansas State, 14-39 | | Nov 13 - L vs. Oklahoma State, 16-33 | | Nov 20 - W vs. Fla Atlantic, 51-17 | | Nov 25 - L vs. Texas A&M, 17-24 |
| | Texas Tech Red Raiders | | Sep 5 - W vs. SMU, 35-27 | | Sep 11 - W at New Mexico, 52-17 | | Sep 18 - L vs. Texas, 14-24 | | Sep 25 - Open | | Oct 2 - L at Iowa State, 38-52 | | Oct 9 - W vs. Baylor, 45-38 | | Oct 16 - L vs. Oklahoma State, 17-34 | | Oct 23 - W at Colorado, 27-24 | | Oct 30 - L at Texas A&M, 27-45 | | Nov 6 - W vs. Missouri, 24-17 | | Nov 13 - L at Oklahoma, 7-45 | | Nov 20 - W vs. Weber State, 64-21 | | Nov 27 - W vs. Houston, 35-20 | | Dec 4 - Open | | Dec 11 - Open | | Jan 1 - W vs. Northwestern, 45-38 |
| | West Virginia Mountaineers | | Sep 4 - W vs. Coastal Carolina, 31-0 | | Sep 10 - W at Marshall, 24-21 OT | | Sep 18 - W vs. Maryland, 31-17 | | Sep 25 - L at LSU, 14-20 | | Oct 2 - Open | | Oct 9 - W vs. UNLV, 49-10 | | Oct 14 - W vs. So Florida, 20-6 | | Oct 23 - L vs. Syracuse, 14-19 | | Oct 29 - L at Connecticut, 13-16 OT | | Nov 6 - Open | | Nov 13 - W vs. Cincinnati, 37-10 | | Nov 20 - W at Louisville, 17-10 | | Nov 26 - W at Pittsburgh, 35-10 | | Dec 4 - W vs. Rutgers, 35-14 | | Dec 11 - Open | | Dec 28 - L at NC State, 7-23 |
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