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| Scoring Summary |
| 1st Quarter |
| San Francisco Field Goal - 19-yarder by David Akers. (6 plays, 79 yards. Time of Drive: 3:17). 7:25 Time Remaining. |
| 2nd Quarter |
| Buffalo Field Goal - 31-yarder by Rian Lindell. (12 plays, 75 yards. Time of Drive: 5:44). 10:46 Time Remaining. |
| San Francisco Touchdown - 43-yard pass from Alex Smith to Kyle Williams. (David Akers extra point is good). (2 plays, 74 yards. Time of Drive: 0:52). 9:54 Time Remaining. |
| San Francisco Touchdown - 28-yard pass from Alex Smith to Michael Crabtree. (David Akers extra point is good). (1 plays, 28 yards. Time of Drive: 0:05). 0:24 Time Remaining. |
| 3rd Quarter |
| San Francisco Touchdown - 1-yard run by Frank Gore. (David Akers extra point is good). (5 plays, 66 yards. Time of Drive: 2:44). 9:06 Time Remaining. |
| 4th Quarter |
| San Francisco Touchdown - 10-yard pass from Alex Smith to Mario Manningham. (David Akers extra point is good). (13 plays, 94 yards. Time of Drive: 7:48). 14:12 Time Remaining. |
| San Francisco Touchdown - 16-yard run by Colin Kaepernick. (David Akers extra point is good). (7 plays, 67 yards. Time of Drive: 3:05). 9:55 Time Remaining. |
| San Francisco Touchdown - 3-yard run by Anthony Dixon. (David Akers extra point is good). (11 plays, 69 yards. Time of Drive: 6:29). 1:11 Time Remaining. |
