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| Wednesday, September 5 - Week 1 |
| Visitor | Home | Time | Network |
| Dallas | NY Giants | 8:30 PM ET | NBC |
| Sunday, September 9 - Week 1 |
| Visitor | Home | Time | Network |
| Indianapolis | Chicago | 1:00 PM ET | CBS |
| Jacksonville | Minnesota | 1:00 PM ET | CBS |
| Buffalo | NY Jets | 1:00 PM ET | CBS |
| Miami | Houston | 1:00 PM ET | CBS |
| New England | Tennessee | 1:00 PM ET | CBS |
| St. Louis | Detroit | 1:00 PM ET | FOX |
| Washington | New Orleans | 1:00 PM ET | FOX |
| Philadelphia | Cleveland | 1:00 PM ET | FOX |
| Atlanta | Kansas City | 1:00 PM ET | FOX |
| San Francisco | Green Bay | 4:15 PM ET | FOX |
| Seattle | Arizona | 4:15 PM ET | FOX |
| Carolina | Tampa Bay | 4:15 PM ET | FOX |
| Pittsburgh | Denver | 8:20 PM ET | NBC |
| Monday, September 10 - Week 1 |
| Visitor | Home | Time | Network |
| Cincinnati | Baltimore | 7:00 PM ET | ESPN |
| San Diego | Oakland | 10:15 PM ET | ESPN |
| Thursday, September 13 - Week 2 |
| Visitor | Home | Time | Network |
| Chicago | Green Bay | 8:20 PM ET | NFL Network |
| Sunday, September 16 - Week 2 |
| Visitor | Home | Time | Network |
| Tampa Bay | NY Giants | 1:00 PM ET | FOX |
| New Orleans | Carolina | 1:00 PM ET | FOX |
| Arizona | New England | 1:00 PM ET | FOX |
| Minnesota | Indianapolis | 1:00 PM ET | FOX |
| Baltimore | Philadelphia | 1:00 PM ET | CBS |
| Kansas City | Buffalo | 1:00 PM ET | CBS |
| Cleveland | Cincinnati | 1:00 PM ET | CBS |
| Houston | Jacksonville | 1:00 PM ET | CBS |
| Dallas | Seattle | 4:05 PM ET | FOX |
| Washington | St. Louis | 4:05 PM ET | FOX |
| NY Jets | Pittsburgh | 4:15 PM ET | CBS |
| Oakland | Miami | 4:15 PM ET | CBS |
| Tennessee | San Diego | 4:15 PM ET | CBS |
| Detroit | San Francisco | 8:20 PM ET | NBC |
| Monday, September 17 - Week 2 |
| Visitor | Home | Time | Network |
| Denver | Atlanta | 8:30 PM ET | ESPN |
| Thursday, September 20 - Week 3 |
| Visitor | Home | Time | Network |
| NY Giants | Carolina | 8:20 PM ET | NFL Network |
| Sunday, September 23 - Week 3 |
| Visitor | Home | Time | Network |
| Tampa Bay | Dallas | 1:00 PM ET | FOX |
| St. Louis | Chicago | 1:00 PM ET | FOX |
| San Francisco | Minnesota | 1:00 PM ET | FOX |
| Detroit | Tennessee | 1:00 PM ET | FOX |
| Cincinnati | Washington | 1:00 PM ET | CBS |
| Kansas City | New Orleans | 1:00 PM ET | CBS |
| NY Jets | Miami | 1:00 PM ET | CBS |
| Buffalo | Cleveland | 1:00 PM ET | CBS |
| Jacksonville | Indianapolis | 1:00 PM ET | CBS |
| Philadelphia | Arizona | 4:05 PM ET | FOX |
| Atlanta | San Diego | 4:05 PM ET | FOX |
| Houston | Denver | 4:15 PM ET | CBS |
| Pittsburgh | Oakland | 4:15 PM ET | CBS |
| New England | Baltimore | 8:20 PM ET | NBC |
| Monday, September 24 - Week 3 |
| Visitor | Home | Time | Network |
| Green Bay | Seattle | 8:30 PM ET | ESPN |
| Thursday, September 27 - Week 4 |
| Visitor | Home | Time | Network |
| Cleveland | Baltimore | 8:20 PM ET | NFL Network |
| Sunday, September 30 - Week 4 |
| Visitor | Home | Time | Network |
| New England | Buffalo | 1:00 PM ET | CBS |
| Tennessee | Houston | 1:00 PM ET | CBS |
| San Diego | Kansas City | 1:00 PM ET | CBS |
| Minnesota | Detroit | 1:00 PM ET | FOX |
| Carolina | Atlanta | 1:00 PM ET | FOX |
| Seattle | St. Louis | 1:00 PM ET | FOX |
| San Francisco | NY Jets | 1:00 PM ET | FOX |
| Miami | Arizona | 4:05 PM ET | CBS |
| Oakland | Denver | 4:05 PM ET | CBS |
| Cincinnati | Jacksonville | 4:05 PM ET | CBS |
| New Orleans | Green Bay | 4:15 PM ET | FOX |
| Washington | Tampa Bay | 4:15 PM ET | FOX |
| NY Giants | Philadelphia | 8:20 PM ET | NBC |
| Monday, October 1 - Week 4 |
| Visitor | Home | Time | Network |
| Chicago | Dallas | 8:30 PM ET | ESPN |
| Thursday, October 4 - Week 5 |
| Visitor | Home | Time | Network |
| Arizona | St. Louis | 8:20 PM ET | NFL Network |
| Sunday, October 7 - Week 5 |
| Visitor | Home | Time | Network |
| Atlanta | Washington | 1:00 PM ET | FOX |
| Philadelphia | Pittsburgh | 1:00 PM ET | FOX |
| Green Bay | Indianapolis | 1:00 PM ET | FOX |
| Tennessee | Minnesota | 1:00 PM ET | CBS |
| Miami | Cincinnati | 1:00 PM ET | CBS |
| Baltimore | Kansas City | 1:00 PM ET | CBS |
| Cleveland | NY Giants | 1:00 PM ET | CBS |
| Seattle | Carolina | 4:05 PM ET | FOX |
| Chicago | Jacksonville | 4:05 PM ET | FOX |
| Denver | New England | 4:15 PM ET | CBS |
| Buffalo | San Francisco | 4:15 PM ET | CBS |
| San Diego | New Orleans | 8:20 PM ET | NBC |
| Monday, October 8 - Week 5 |
| Visitor | Home | Time | Network |
| Houston | NY Jets | 8:30 PM ET | ESPN |
| Thursday, October 11 - Week 6 |
| Visitor | Home | Time | Network |
| Pittsburgh | Tennessee | 8:20 PM ET | NFL Network |
| Sunday, October 14 - Week 6 |
| Visitor | Home | Time | Network |
| Oakland | Atlanta | 1:00 PM ET | CBS |
| Kansas City | Tampa Bay | 1:00 PM ET | CBS |
| Indianapolis | NY Jets | 1:00 PM ET | CBS |
| Cincinnati | Cleveland | 1:00 PM ET | CBS |
| Detroit | Philadelphia | 1:00 PM ET | FOX |
| St. Louis | Miami | 1:00 PM ET | FOX |
| Dallas | Baltimore | 1:00 PM ET | FOX |
| Buffalo | Arizona | 4:05 PM ET | CBS |
| New England | Seattle | 4:05 PM ET | CBS |
| NY Giants | San Francisco | 4:15 PM ET | FOX |
| Minnesota | Washington | 4:15 PM ET | FOX |
| Green Bay | Houston | 8:20 PM ET | NBC |
| Monday, October 15 - Week 6 |
| Visitor | Home | Time | Network |
| Denver | San Diego | 8:30 PM ET | ESPN |
| Thursday, October 18 - Week 7 |
| Visitor | Home | Time | Network |
| Seattle | San Francisco | 8:20 PM ET | NFL Network |
| Sunday, October 21 - Week 7 |
| Visitor | Home | Time | Network |
| Washington | NY Giants | 1:00 PM ET | FOX |
| Arizona | Minnesota | 1:00 PM ET | FOX |
| Dallas | Carolina | 1:00 PM ET | FOX |
| New Orleans | Tampa Bay | 1:00 PM ET | FOX |
| Green Bay | St. Louis | 1:00 PM ET | FOX |
| Baltimore | Houston | 1:00 PM ET | CBS |
| Cleveland | Indianapolis | 1:00 PM ET | CBS |
| Tennessee | Buffalo | 1:00 PM ET | CBS |
| NY Jets | New England | 4:15 PM ET | CBS |
| Jacksonville | Oakland | 4:15 PM ET | CBS |
| Pittsburgh | Cincinnati | 8:20 PM ET | NBC |
| Monday, October 22 - Week 7 |
| Visitor | Home | Time | Network |
| Detroit | Chicago | 8:30 PM ET | ESPN |
| Thursday, October 25 - Week 8 |
| Visitor | Home | Time | Network |
| Tampa Bay | Minnesota | 8:20 PM ET | NFL Network |
| Sunday, October 28 - Week 8 |
| Visitor | Home | Time | Network |
| Jacksonville | Green Bay | 1:00 PM ET | CBS |
| Miami | NY Jets | 1:00 PM ET | CBS |
| San Diego | Cleveland | 1:00 PM ET | CBS |
| Indianapolis | Tennessee | 1:00 PM ET | CBS |
| Atlanta | Philadelphia | 1:00 PM ET | FOX |
| Carolina | Chicago | 1:00 PM ET | FOX |
| Seattle | Detroit | 1:00 PM ET | FOX |
| Washington | Pittsburgh | 1:00 PM ET | FOX |
| New England | St. Louis | 1:00 PM ET | CBS |
| Oakland | Kansas City | 4:05 PM ET | CBS |
| NY Giants | Dallas | 4:15 PM ET | FOX |
| New Orleans | Denver | 8:20 PM ET | NBC |
| Monday, October 29 - Week 8 |
| Visitor | Home | Time | Network |
| San Francisco | Arizona | 8:30 PM ET | ESPN |
| Thursday, November 1 - Week 9 |
| Visitor | Home | Time | Network |
| Kansas City | San Diego | 8:20 PM ET | NFL Network |
| Sunday, November 4 - Week 9 |
| Visitor | Home | Time | Network |
| Carolina | Washington | 1:00 PM ET | FOX |
| Arizona | Green Bay | 1:00 PM ET | FOX |
| Detroit | Jacksonville | 1:00 PM ET | FOX |
| Chicago | Tennessee | 1:00 PM ET | FOX |
| Miami | Indianapolis 1:00 PM ET | CBS |
| Buffalo | Houston | 1:00 PM ET | CBS |
| Denver | Cincinnati | 1:00 PM ET | CBS |
| Baltimore | Cleveland | 1:00 PM ET | CBS |
| Minnesota | Seattle | 4:05 PM ET | FOX |
| Tampa Bay | Oakland | 4:05 PM ET | FOX |
| Pittsburgh | NY Giants | 4:15 PM ET | CBS |
| Dallas | Atlanta | 8:20 PM ET | NBC |
| Monday, November 5 - Week 9 |
| Visitor | Home | Time | Network |
| Philadelphia | New Orleans | 8:30 PM ET | ESPN |
| Thursday, November 8 - Week 10 |
| Visitor | Home | Time | Network |
| Indianapolis | Jacksonville | 8:20 PM ET | NFL Network |
| Sunday, November 11 - Week 10 |
| Visitor | Home | Time | Network |
| Denver | Carolina | 1:00 PM ET | CBS |
| Detroit | Minnesota | 1:00 PM ET | FOX |
| NY Giants | Cincinnati | 1:00 PM ET | FOX |
| Atlanta | New Orleans | 1:00 PM ET | FOX |
| Buffalo | New England | 1:00 PM ET | CBS |
| Oakland | Baltimore | 1:00 PM ET | CBS |
| San Diego | Tampa Bay | 1:00 PM ET | CBS |
| Tennessee | Miami | 1:00 PM ET | CBS |
| NY Jets | Seattle | 4:05 PM ET | CBS |
| Dallas | Philadelphia | 4:15 PM ET | FOX |
| St. Louis | San Francisco | 4:15 PM ET | FOX |
| Houston | Chicago | 8:20 PM ET | NBC |
| Monday, November 12 - Week 10 |
| Visitor | Home | Time | Network |
| Kansas City | Pittsburgh | 8:30 PM ET | ESPN |
| Thursday, November 15 - Week 11 |
| Visitor | Home | Time | Network |
| Miami | Buffalo | 8:20 PM ET | NFL Network |
| Sunday, November 18 - Week 11 |
| Visitor | Home | Time | Network |
| Jacksonville | Houston | 1:00 PM ET | CBS |
| Cincinnati | Kansas City | 1:00 PM ET | CBS |
| Indianapolis | New England | 1:00 PM ET | CBS |
| Cleveland | Dallas | 1:00 PM ET | CBS |
| Green Bay | Detroit | 1:00 PM ET | FOX |
| NY Jets | St. Louis | 1:00 PM ET | CBS |
| Tampa Bay | Carolina | 1:00 PM ET | FOX |
| Arizona | Atlanta | 1:00 PM ET | FOX |
| Philadelphia | Washington | 1:00 PM ET | FOX |
| New Orleans | Oakland | 4:05 PM ET | FOX |
| San Diego | Denver | 4:15 PM ET | CBS |
| Baltimore | Pittsburgh | 8:20 PM ET | NBC |
| Monday, November 19 - Week 11 |
| Visitor | Home | Time | Network |
| Chicago | San Francisco | 8:30 PM ET | ESPN |
| Thursday, November 22 - Week 12 |
| Visitor | Home | Time | Network |
| Houston | Detroit | 12:30 PM ET | CBS |
| Washington | Dallas | 4:15 PM ET | FOX |
| New England | NY Jets | 8:20 PM ET | NBC |
| Sunday, November 25 - Week 12 |
| Visitor | Home | Time | Network |
| Oakland | Cincinnati | 1:00 PM ET | CBS |
| Pittsburgh | Cleveland | 1:00 PM ET | CBS |
| Denver | Kansas City | 1:00 PM ET | CBS |
| Tennessee | Jacksonville | 1:00 PM ET | CBS |
| Buffalo | Indianapolis | 1:00 PM ET | CBS |
| Seattle | Miami | 1:00 PM ET | FOX |
| Atlanta | Tampa Bay | 1:00 PM ET | FOX |
| Minnesota | Chicago | 1:00 PM ET | FOX |
| Baltimore | San Diego | 4:05 PM ET | CBS |
| San Francisco | New Orleans | 4:15 PM ET | FOX |
| St. Louis | Arizona | 4:15 PM ET | FOX |
| Green Bay | NY Giants | 8:20 PM ET | NBC |
| Monday, November 26 - Week 12 |
| Visitor | Home | Time | Network |
| Carolina | Philadelphia | 8:30 PM ET | ESPN |
| Thursday, November 29 - Week 13 |
| Visitor | Home | Time | Network |
| New Orleans | Atlanta | 8:20 PM ET | NFL Network |
| Sunday, December 2 - Week 13 |
| Visitor | Home | Time | Network |
| Houston | Tennessee | 1:00 PM ET | CBS |
| New England | Miami | 1:00 PM ET | CBS |
| Indianapolis | Detroit | 1:00 PM ET | CBS |
| Jacksonville | Buffalo | 1:00 PM ET | CBS |
| Carolina | Kansas City | 1:00 PM ET | FOX |
| Arizona | NY Jets | 1:00 PM ET | FOX |
| San Francisco | St. Louis | 1:00 PM ET | FOX |
| Minnesota | Green Bay | 1:00 PM ET | FOX |
| Seattle | Chicago | 1:00 PM ET | FOX |
| Tampa Bay | Denver | 4:05 PM ET | FOX |
| Pittsburgh | Baltimore | 4:15 PM ET | CBS |
| Cleveland | Oakland | 4:15 PM ET | CBS |
| Cincinnati | San Diego | 4:15 PM ET | CBS |
| Philadelphia | Dallas | 8:20 PM ET | NBC |
| Monday, December 3 - Week 13 |
| Visitor | Home | Time | Network |
| NY Giants | Washington | 8:30 PM ET | ESPN |
| Wednesday, December 5 - Week 14 |
| Visitor | Home | Time | Network |
| Denver Oakland 8:20 PM ET NFL Network |
| Sunday, December 9 - Week 14 |
| Visitor | Home | Time | Network |
| San Diego | Pittsburgh | 1:00 PM ET | CBS |
| Baltimore | Washington | 1:00 PM ET | CBS |
| Kansas City | Cleveland | 1:00 PM ET | CBS |
| Tennessee | Indianapolis | 1:00 PM ET | CBS |
| NY Jets | Jacksonville | 1:00 PM ET | CBS |
| Chicago | Minnesota | 1:00 PM ET | FOX |
| Atlanta | Carolina | 1:00 PM ET | FOX |
| Dallas | Cincinnati | 1:00 PM ET | FOX |
| St. Louis | Buffalo | 1:00 PM ET | FOX |
| Philadelphia | Tampa Bay | 1:00 PM ET | FOX |
| Miami | San Francisco | 4:05 PM ET | CBS |
| New Orleans | NY Giants | 4:15 PM ET | FOX |
| Arizona | Seattle | 4:15 PM ET | FOX |
| Detroit | Green Bay | 8:20 PM ET | NBC |
| Monday, December 10 - Week 14 |
| Visitor | Home | Time | Network |
| Houston | New England | 8:30 PM ET | ESPN |
| Thursday, December 13 - Week 15 |
| Visitor | Home | Time | Network |
| Cincinnati | Philadelphia | 8:20 PM ET | NFL Network |
| Sunday, December 16 - Week 15 |
| Visitor | Home | Time | Network |
| Green Bay | Chicago | 1:00 PM ET | FOX |
| NY Giants | Atlanta | 1:00 PM ET | FOX |
| Tampa Bay | New Orleans | 1:00 PM ET | FOX |
| Washington | Cleveland | 1:00 PM ET | FOX |
| Minnesota | St. Louis | 1:00 PM ET | FOX |
| Jacksonville | Miami | 1:00 PM ET | CBS |
| Denver | Baltimore | 1:00 PM ET | CBS |
| Indianapolis | Houston | 1:00 PM ET | CBS |
| Carolina | San Diego | 4:05 PM ET | FOX |
| Detroit | Arizona | 4:05 PM ET | FOX |
| Seattle | Buffalo | 4:05 PM ET | FOX |
| Pittsburgh | Dallas | 4:15 PM ET | CBS |
| Kansas City | Oakland | 4:15 PM ET | CBS |
| San Francisco | New England | 8:20 PM ET | NBC |
| Monday, December 17 - Week 15 |
| Visitor | Home | Time | Network |
| NY Jets | Tennessee | 8:30 PM ET | ESPN |
| Saturday, December 22 - Week 16 |
| Visitor | Home | Time | Network |
| Atlanta | Detroit | 8:30 PM ET | ESPN |
| Sunday, December 23 - Week 16 |
| Visitor | Home | Time | Network |
| Tennessee | Green Bay | 1:00 PM ET | CBS |
| Oakland | Carolina | 1:00 PM ET | CBS |
| Buffalo | Miami | 1:00 PM ET | CBS |
| Cincinnati | Pittsburgh | 1:00 PM ET | CBS |
| New England | Jacksonville | 1:00 PM ET | CBS |
| Indianapolis | Kansas City | 1:00 PM ET | CBS |
| Minnesota | Houston | 1:00 PM ET | FOX |
| NY Giants | Baltimore | 1:00 PM ET | FOX |
| St. Louis | Tampa Bay | 1:00 PM ET | FOX |
| Washington | Philadelphia | 1:00 PM ET | FOX |
| New Orleans | Dallas | 1:00 PM ET | FOX |
| Cleveland | Denver | 4:05 PM ET | CBS |
| Chicago | Arizona | 4:15 PM ET | FOX |
| San Francisco | Seattle | 4:15 PM ET | FOX |
| San Diego | NY Jets | 8:20 PM ET | NBC |
| Sunday, December 30 - Week 17 |
| Visitor | Home | Time | Network |
| NY Jets | Buffalo | 1:00 PM ET | CBS |
| Jacksonville | Tennessee | 1:00 PM ET | CBS |
| Houston | Indianapolis | 1:00 PM ET | CBS |
| Cleveland | Pittsburgh | 1:00 PM ET | CBS |
| Baltimore | Cincinnati | 1:00 PM ET | CBS |
| Miami | New England | 1:00 PM ET | CBS |
| Green Bay | Minnesota | 1:00 PM ET | FOX |
| Chicago | Detroit | 1:00 PM ET | FOX |
| Philadelphia | NY Giants | 1:00 PM ET | FOX |
| Dallas | Washington | 1:00 PM ET | FOX |
| Tampa Bay | Atlanta | 1:00 PM ET | FOX |
| Carolina | New Orleans | 1:00 PM ET | FOX |
| Kansas City | Denver | 4:15 PM ET | CBS |
| Arizona | San Francisco | 4:15 PM ET | FOX |
| Oakland | San Diego | 4:15 PM ET | CBS |
| St. Louis | Seattle | 4:15 PM ET | FOX |
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