| August 2021 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sat. 14 | 1 | 8:00 AM PT9:00 AM MT10:00 AM CT11:00 AM ET15:00 GMT16:00 15:00 3:00 PM 17:00 KSA2:00 AM AET20:30 IST10:30 AM VEN19:00 UAE11:00 PM SST23:00 22:00 8:00 AM MST9:00 AM CST10:00 AM EST11:00 ET10:00 12:00 BRT11:00 10:00 AM CT | Leganés | Reale Arena | W 1-0 |
| Sat. 21 | 2 | 8:00 AM PT9:00 AM MT10:00 AM CT11:00 AM ET15:00 GMT16:00 15:00 3:00 PM 17:00 KSA2:00 AM AET20:30 IST10:30 AM VEN19:00 UAE11:00 PM SST23:00 22:00 8:00 AM MST9:00 AM CST10:00 AM EST11:00 ET10:00 12:00 BRT11:00 10:00 AM CT | Lugo | Estadio Anxo Carro | D 0-0 |
| Sun. 29 | 3 | 10:30 AM PT11:30 AM MT12:30 PM CT1:30 PM ET17:30 GMT18:30 17:30 5:30 PM 19:30 KSA4:30 AM AET23:00 IST1:00 PM VEN21:30 UAE1:30 AM SST1:30 0:30 10:30 AM MST11:30 AM CST12:30 PM EST13:30 ET12:30 14:30 BRT13:30 12:30 PM CT | Fuenlabrada | Reale Arena | D 0-0 |
| September 2021 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sat. 4 | 4 | 9:15 AM PT10:15 AM MT11:15 AM CT12:15 PM ET16:15 GMT17:15 16:15 4:15 PM 18:15 KSA3:15 AM AET21:45 IST11:45 AM VEN20:15 UAE12:15 AM SST0:15 23:15 9:15 AM MST10:15 AM CST11:15 AM EST12:15 ET11:15 13:15 BRT12:15 11:15 AM CT | FC Cartagena | Estadio Municipal Cartagonova | L 0-1 |
| Sat. 11 | 5 | 7:00 AM PT8:00 AM MT9:00 AM CT10:00 AM ET14:00 GMT15:00 14:00 2:00 PM 16:00 KSA1:00 AM AET19:30 IST9:30 AM VEN18:00 UAE10:00 PM SST22:00 21:00 7:00 AM MST8:00 AM CST9:00 AM EST10:00 ET9:00 11:00 BRT10:00 9:00 AM CT | Eibar | Reale Arena | L 2-3 |
| Sat. 18 | 6 | 9:15 AM PT10:15 AM MT11:15 AM CT12:15 PM ET16:15 GMT17:15 16:15 4:15 PM 18:15 KSA3:15 AM AET21:45 IST11:45 AM VEN20:15 UAE12:15 AM SST0:15 23:15 9:15 AM MST10:15 AM CST11:15 AM EST12:15 ET11:15 13:15 BRT12:15 11:15 AM CT | Real Zaragoza | Estadio de la Romareda | D 1-1 |
| Fri. 24 | 7 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET18:00 GMT19:00 18:00 6:00 PM 20:00 KSA5:00 AM AET23:30 IST1:30 PM VEN22:00 UAE2:00 AM SST2:00 1:00 11:00 AM MST12:00 PM CST1:00 PM EST14:00 ET13:00 15:00 BRT14:00 1:00 PM CT | Huesca | Reale Arena | L 0-2 |
| October 2021 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sat. 2 | 8 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT | Alcorcón | Estadio Santo Domingo | W 4-1 |
| Sun. 10 | 9 | 5:00 AM PT6:00 AM MT7:00 AM CT8:00 AM ET12:00 GMT13:00 12:00 12:00 PM 14:00 KSA11:00 PM AET17:30 IST7:30 AM VEN16:00 UAE8:00 PM SST20:00 19:00 5:00 AM MST6:00 AM CST7:00 AM EST8:00 ET7:00 9:00 BRT8:00 7:00 AM CT | Ponferradina | Estadio Municipal de Ipurua | D 1-1 |
| Sun. 17 | 10 | 9:15 AM PT10:15 AM MT11:15 AM CT12:15 PM ET16:15 GMT17:15 16:15 4:15 PM 18:15 KSA3:15 AM AET21:45 IST11:45 AM VEN20:15 UAE12:15 AM SST0:15 23:15 9:15 AM MST10:15 AM CST11:15 AM EST12:15 ET11:15 13:15 BRT12:15 11:15 AM CT | Real Oviedo | Reale Arena | D 1-1 |
| Thu. 21 | 11 | 9:45 AM PT10:45 AM MT11:45 AM CT12:45 PM ET16:45 GMT17:45 16:45 4:45 PM 18:45 KSA3:45 AM AET22:15 IST12:15 PM VEN20:45 UAE12:45 AM SST0:45 23:45 9:45 AM MST10:45 AM CST11:45 AM EST12:45 ET11:45 13:45 BRT12:45 11:45 AM CT | Almería | Juegos Mediterráneos | L 1-3 |
| Sun. 24 | 12 | 5:00 AM PT6:00 AM MT7:00 AM CT8:00 AM ET12:00 GMT13:00 12:00 12:00 PM 14:00 KSA11:00 PM AET17:30 IST7:30 AM VEN16:00 UAE8:00 PM SST20:00 19:00 5:00 AM MST6:00 AM CST7:00 AM EST8:00 ET7:00 9:00 BRT8:00 7:00 AM CT | Amorebieta | Instalaciones de Lezama Campo 2 | W 2-1 |
| Fri. 29 | 13 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT | Las Palmas | Reale Arena | L 0-1 |
| November 2021 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Thu. 4 | 14 | 1:15 PM PT2:15 PM MT3:15 PM CT4:15 PM ET20:15 GMT21:15 20:15 8:15 PM 22:15 KSA7:15 AM AET1:45 (+1) IST3:45 PM VEN0:15 (+1) UAE4:15 AM SST4:15 3:15 1:15 PM MST2:15 PM CST3:15 PM EST16:15 ET15:15 17:15 BRT16:15 2:15 PM CT | Málaga | Estadio La Rosaleda | L 1-2 |
| Sun. 7 | 15 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 17:00 BRT16:00 1:00 PM CT | Ibiza | Reale Arena | L 0-1 |
| Fri. 12 | 16 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 16:00 BRT16:00 1:00 PM CT | Sporting de Gijón | El Molinón | W 1-0 |
| Mon. 22 | 17 | 10:00 AM PT11:00 AM MT12:00 PM CT1:00 PM ET18:00 GMT19:00 18:00 6:00 PM 20:00 KSA5:00 AM AET23:30 IST1:30 PM VEN22:00 UAE2:00 AM SST2:00 1:00 11:00 AM MST12:00 PM CST1:00 PM EST13:00 ET13:00 14:00 BRT14:00 11:00 AM CT | Girona | Reale Arena | L 1-2 |
| Sun. 28 | 18 | 9:15 AM PT10:15 AM MT11:15 AM CT12:15 PM ET17:15 GMT18:15 17:15 5:15 PM 19:15 KSA4:15 AM AET22:45 IST12:45 PM VEN21:15 UAE1:15 AM SST1:15 0:15 10:15 AM MST11:15 AM CST12:15 PM EST12:15 ET12:15 13:15 BRT13:15 10:15 AM CT | Tenerife | Estadio Heliodoro Rodriguez Lopez | L 0-2 |
| December 2021 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sun. 5 | 19 | 9:15 AM PT10:15 AM MT11:15 AM CT12:15 PM ET17:15 GMT18:15 17:15 5:15 PM 19:15 KSA4:15 AM AET22:45 IST12:45 PM VEN21:15 UAE1:15 AM SST1:15 0:15 10:15 AM MST11:15 AM CST12:15 PM EST12:15 ET12:15 13:15 BRT13:15 10:15 AM CT | Burgos | Centro de Entrenamiento Zubieta | |
| Mon. 13 | 20 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 16:00 BRT16:00 1:00 PM CT | Mirandés | Estadio Municipal de Anduva | |
| Sun. 19 | 21 | 9:15 AM PT10:15 AM MT11:15 AM CT12:15 PM ET17:15 GMT18:15 17:15 5:15 PM 19:15 KSA4:15 AM AET22:45 IST12:45 PM VEN21:15 UAE1:15 AM SST1:15 0:15 10:15 AM MST11:15 AM CST12:15 PM EST12:15 ET12:15 13:15 BRT13:15 10:15 AM CT | Real Valladolid | Reale Arena | |
| Fri. 31 | 22 | 7:15 AM PT8:15 AM MT9:15 AM CT10:15 AM ET15:15 GMT16:15 15:15 3:15 PM 17:15 KSA2:15 AM AET20:45 IST10:45 AM VEN19:15 UAE11:15 PM SST23:15 22:15 8:15 AM MST9:15 AM CST10:15 AM EST10:15 ET10:15 11:15 BRT11:15 8:15 AM CT | Eibar | Estadio Municipal de Ipurua | |
| January 2022 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sun. 9 | 23 | TBA | Leganés | Estadio Municipal de Butarque | |
| Sun. 23 | 24 | TBA | FC Cartagena | Reale Arena | |
| Sun. 30 | 25 | TBA | Las Palmas | Estadio de Gran Canaria | |
| February 2022 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sun. 6 | 26 | TBA | Lugo | Reale Arena | |
| Sun. 13 | 27 | TBA | Ponferradina | El Toralín | |
| Sun. 20 | 28 | TBA | Málaga | Reale Arena | |
| Sun. 27 | 29 | TBA | Real Oviedo | Estadio Nuevo Carlos Tartiere | |
| March 2022 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sun. 6 | 30 | TBA | Sporting de Gijón | Reale Arena | |
| Sun. 13 | 31 | TBA | Burgos | Estadio Municipal de El Plantio | |
| Sun. 20 | 32 | TBA | Mirandés | Reale Arena | |
| Sun. 27 | 33 | TBA | Ibiza | Estadio Can Misses ? Power Electronic | |
| April 2022 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sun. 3 | 34 | TBA | Alcorcón | Reale Arena | |
| Sun. 10 | 35 | TBA | Tenerife | Reale Arena | |
| Sun. 17 | 36 | TBA | Girona | Estadi Municipal de Montilivi | |
| Sun. 24 | 37 | TBA | Amorebieta | Reale Arena | |
| May 2022 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sun. 1 | 38 | TBA | Real Valladolid | José Zorrilla | |
| Sun. 8 | 39 | TBA | Fuenlabrada | Estadio Fernando Torres | |
| Sun. 15 | 40 | TBA | Almería | Reale Arena | |
| Sun. 22 | 41 | TBA | Huesca | Estadio El Alcoraz | |
| Sun. 29 | 42 | TBA | Real Zaragoza | Reale Arena | |
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