| Friday, 1 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 2-2 |
8 | Ponferradina |
Real Valladolid | El Toralín |
| Saturday, 2 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 1-2 |
8 | Huesca |
Tenerife | Estadio El Alcoraz |
| 1-1 |
8 | Amorebieta |
Sporting de Gijón | Instalaciones de Lezama Campo 2 |
| 0-0 |
8 | Real Zaragoza |
Real Oviedo | Estadio de la Romareda |
| 1-4 |
8 | Alcorcón |
Real Sociedad II | Estadio Santo Domingo |
| Sunday, 3 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 3-1 |
8 | Eibar |
Ibiza | Estadio Municipal de Ipurua |
| 1-0 |
8 | Málaga |
Fuenlabrada | Estadio La Rosaleda |
| 4-1 |
8 | Las Palmas |
FC Cartagena | Estadio de Gran Canaria |
| 1-0 |
8 | Burgos |
Mirandés | Estadio Municipal de El Plantio |
| 1-1 |
8 | Leganés |
Lugo | Estadio Municipal de Butarque |
| Monday, 4 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 1-2 |
8 | Girona |
Almería | Estadi Municipal de Montilivi |
| Friday, 8 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 1-1 |
9 | Real Valladolid |
Málaga | José Zorrilla |
| Saturday, 9 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 3-3 |
9 | Mirandés |
Eibar | Estadio Municipal de Anduva |
| 1-0 |
9 | Lugo |
Girona | Estadio Anxo Carro |
| 1-1 |
9 | Almería |
Las Palmas | Juegos Mediterráneos |
| 1-1 |
9 | Real Oviedo |
Sporting de Gijón | Estadio Nuevo Carlos Tartiere |
| Sunday, 10 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 1-1 |
9 | Real Sociedad II |
Ponferradina | Estadio Municipal de Ipurua |
| 5-1 |
9 | FC Cartagena |
Ibiza | Estadio Municipal Cartagonova |
| 2-1 |
9 | Tenerife |
Amorebieta | Estadio Heliodoro Rodriguez Lopez |
| 1-0 |
9 | Alcorcón |
Burgos | Estadio Santo Domingo |
| 2-1 |
9 | Fuenlabrada |
Leganés | Estadio Fernando Torres |
| Monday, 11 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 0-0 |
9 | Real Zaragoza |
Huesca | Estadio de la Romareda |
| Friday, 15 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 1-0 |
10 | Eibar |
Almería | Estadio Municipal de Ipurua |
| Saturday, 16 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 1-3 |
10 | Girona |
Huesca | Estadi Municipal de Montilivi |
| 2-3 |
10 | Amorebieta |
FC Cartagena | Instalaciones de Lezama Campo 2 |
| 2-1 |
10 | Las Palmas |
Tenerife | Estadio de Gran Canaria |
| 1-1 |
10 | Málaga |
Real Zaragoza | Estadio La Rosaleda |
| 1-0 |
10 | Sporting de Gijón |
Alcorcón | El Molinón |
| Sunday, 17 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 0-2 |
10 | Ibiza |
Mirandés | Estadio Can Misses ? Power Electronic |
| 0-2 |
10 | Leganés |
Real Valladolid | Estadio Municipal de Butarque |
| 1-1 |
10 | Burgos |
Lugo | Estadio Municipal de El Plantio |
| 1-1 |
10 | Real Sociedad II |
Real Oviedo | Reale Arena |
| 0-0 |
10 | Ponferradina |
Fuenlabrada | El Toralín |
| Tuesday, 19 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 10:00 AM PT11:00 AM MT12:00 PM CT1:00 PM ET17:00 GMT18:00 17:00 5:00 PM 19:00 KSA4:00 AM AET22:30 IST12:30 PM VEN21:00 UAE1:00 AM SST1:00 0:00 10:00 AM MST11:00 AM CST12:00 PM EST13:00 ET12:00 14:00 BRT13:00 12:00 PM CT |
11 | Huesca |
Málaga | Estadio El Alcoraz |
| 10:00 AM PT11:00 AM MT12:00 PM CT1:00 PM ET17:00 GMT18:00 17:00 5:00 PM 19:00 KSA4:00 AM AET22:30 IST12:30 PM VEN21:00 UAE1:00 AM SST1:00 0:00 10:00 AM MST11:00 AM CST12:00 PM EST13:00 ET12:00 14:00 BRT13:00 12:00 PM CT |
11 | FC Cartagena |
Sporting de Gijón | Estadio Municipal Cartagonova |
| 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT |
11 | Tenerife |
Eibar | Estadio Heliodoro Rodriguez Lopez |
| Wednesday, 20 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 10:00 AM PT11:00 AM MT12:00 PM CT1:00 PM ET17:00 GMT18:00 17:00 5:00 PM 19:00 KSA4:00 AM AET22:30 IST12:30 PM VEN21:00 UAE1:00 AM SST1:00 0:00 10:00 AM MST11:00 AM CST12:00 PM EST13:00 ET12:00 14:00 BRT13:00 12:00 PM CT |
11 | Real Valladolid |
Ibiza | José Zorrilla |
| 10:00 AM PT11:00 AM MT12:00 PM CT1:00 PM ET17:00 GMT18:00 17:00 5:00 PM 19:00 KSA4:00 AM AET22:30 IST12:30 PM VEN21:00 UAE1:00 AM SST1:00 0:00 10:00 AM MST11:00 AM CST12:00 PM EST13:00 ET12:00 14:00 BRT13:00 12:00 PM CT |
11 | Fuenlabrada |
Amorebieta | Estadio Fernando Torres |
| 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT |
11 | Alcorcón |
Leganés | Estadio Santo Domingo |
| 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT |
11 | Lugo |
Las Palmas | Estadio Anxo Carro |
| Thursday, 21 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 9:45 AM PT10:45 AM MT11:45 AM CT12:45 PM ET16:45 GMT17:45 16:45 4:45 PM 18:45 KSA3:45 AM AET22:15 IST12:15 PM VEN20:45 UAE12:45 AM SST0:45 23:45 9:45 AM MST10:45 AM CST11:45 AM EST12:45 ET11:45 13:45 BRT12:45 11:45 AM CT |
11 | Almería |
Real Sociedad II | Juegos Mediterráneos |
| 10:00 AM PT11:00 AM MT12:00 PM CT1:00 PM ET17:00 GMT18:00 17:00 5:00 PM 19:00 KSA4:00 AM AET22:30 IST12:30 PM VEN21:00 UAE1:00 AM SST1:00 0:00 10:00 AM MST11:00 AM CST12:00 PM EST13:00 ET12:00 14:00 BRT13:00 12:00 PM CT |
11 | Real Zaragoza |
Ponferradina | Estadio de la Romareda |
| 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT |
11 | Real Oviedo |
Burgos | Estadio Nuevo Carlos Tartiere |
| 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT |
11 | Mirandés |
Girona | Estadio Municipal de Anduva |
| Friday, 22 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT |
12 | Eibar |
FC Cartagena | Estadio Municipal de Ipurua |
| Saturday, 23 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 7:00 AM PT8:00 AM MT9:00 AM CT10:00 AM ET14:00 GMT15:00 14:00 2:00 PM 16:00 KSA1:00 AM AET19:30 IST9:30 AM VEN18:00 UAE10:00 PM SST22:00 21:00 7:00 AM MST8:00 AM CST9:00 AM EST10:00 ET9:00 11:00 BRT10:00 9:00 AM CT |
12 | Ibiza |
Fuenlabrada | Estadio Can Misses ? Power Electronic |
| 9:15 AM PT10:15 AM MT11:15 AM CT12:15 PM ET16:15 GMT17:15 16:15 4:15 PM 18:15 KSA3:15 AM AET21:45 IST11:45 AM VEN20:15 UAE12:15 AM SST0:15 23:15 9:15 AM MST10:15 AM CST11:15 AM EST12:15 ET11:15 13:15 BRT12:15 11:15 AM CT |
12 | Sporting de Gijón |
Real Valladolid | El Molinón |
| 11:30 AM PT12:30 PM MT1:30 PM CT2:30 PM ET18:30 GMT19:30 18:30 6:30 PM 20:30 KSA5:30 AM AET0:00 (+1) IST2:00 PM VEN22:30 UAE2:30 AM SST2:30 1:30 11:30 AM MST12:30 PM CST1:30 PM EST14:30 ET13:30 15:30 BRT14:30 1:30 PM CT |
12 | Málaga |
Lugo | Estadio La Rosaleda |
| 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT |
12 | Leganés |
Tenerife | Estadio Municipal de Butarque |
| Sunday, 24 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 5:00 AM PT6:00 AM MT7:00 AM CT8:00 AM ET12:00 GMT13:00 12:00 12:00 PM 14:00 KSA11:00 PM AET17:30 IST7:30 AM VEN16:00 UAE8:00 PM SST20:00 19:00 5:00 AM MST6:00 AM CST7:00 AM EST8:00 ET7:00 9:00 BRT8:00 7:00 AM CT |
12 | Mirandés |
Almería | Estadio Municipal de Anduva |
| 5:00 AM PT6:00 AM MT7:00 AM CT8:00 AM ET12:00 GMT13:00 12:00 12:00 PM 14:00 KSA11:00 PM AET17:30 IST7:30 AM VEN16:00 UAE8:00 PM SST20:00 19:00 5:00 AM MST6:00 AM CST7:00 AM EST8:00 ET7:00 9:00 BRT8:00 7:00 AM CT |
12 | Amorebieta |
Real Sociedad II | Instalaciones de Lezama Campo 2 |
| 9:15 AM PT10:15 AM MT11:15 AM CT12:15 PM ET16:15 GMT17:15 16:15 4:15 PM 18:15 KSA3:15 AM AET21:45 IST11:45 AM VEN20:15 UAE12:15 AM SST0:15 23:15 9:15 AM MST10:15 AM CST11:15 AM EST12:15 ET11:15 13:15 BRT12:15 11:15 AM CT |
12 | Ponferradina |
Real Oviedo | El Toralín |
| 9:15 AM PT10:15 AM MT11:15 AM CT12:15 PM ET16:15 GMT17:15 16:15 4:15 PM 18:15 KSA3:15 AM AET21:45 IST11:45 AM VEN20:15 UAE12:15 AM SST0:15 23:15 9:15 AM MST10:15 AM CST11:15 AM EST12:15 ET11:15 13:15 BRT12:15 11:15 AM CT |
12 | Burgos |
Huesca | Estadio Municipal de El Plantio |
| 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT |
12 | Las Palmas |
Alcorcón | Estadio de Gran Canaria |
| Monday, 25 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT |
12 | Girona |
Real Zaragoza | Estadi Municipal de Montilivi |
| Friday, 29 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT |
13 | Almería |
Leganés | Juegos Mediterráneos |
| 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT |
13 | Real Sociedad II |
Las Palmas | Reale Arena |
| Saturday, 30 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 7:00 AM PT8:00 AM MT9:00 AM CT10:00 AM ET14:00 GMT15:00 14:00 2:00 PM 16:00 KSA1:00 AM AET19:30 IST9:30 AM VEN18:00 UAE10:00 PM SST22:00 21:00 7:00 AM MST8:00 AM CST9:00 AM EST10:00 ET9:00 11:00 BRT10:00 9:00 AM CT |
13 | Huesca |
Amorebieta | Estadio El Alcoraz |
| 9:15 AM PT10:15 AM MT11:15 AM CT12:15 PM ET16:15 GMT17:15 16:15 4:15 PM 18:15 KSA3:15 AM AET21:45 IST11:45 AM VEN20:15 UAE12:15 AM SST0:15 23:15 9:15 AM MST10:15 AM CST11:15 AM EST12:15 ET11:15 13:15 BRT12:15 11:15 AM CT |
13 | Lugo |
Sporting de Gijón | Estadio Anxo Carro |
| 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT |
13 | FC Cartagena |
Ponferradina | Estadio Municipal Cartagonova |
| Sunday, 31 October 2021 |
| Time/Result | Matchday | Home | Away | Venue |
| 6:00 AM PT7:00 AM MT8:00 AM CT9:00 AM ET13:00 GMT14:00 13:00 1:00 PM 15:00 KSA12:00 AM AET18:30 IST8:30 AM VEN17:00 UAE9:00 PM SST21:00 20:00 6:00 AM MST7:00 AM CST8:00 AM EST9:00 ET8:00 10:00 BRT9:00 8:00 AM CT |
13 | Fuenlabrada |
Girona | Estadio Fernando Torres |
| 8:00 AM PT9:00 AM MT10:00 AM CT11:00 AM ET15:00 GMT16:00 15:00 3:00 PM 17:00 KSA2:00 AM AET20:30 IST10:30 AM VEN19:00 UAE11:00 PM SST23:00 22:00 8:00 AM MST9:00 AM CST10:00 AM EST11:00 ET10:00 12:00 BRT11:00 10:00 AM CT |
13 | Real Oviedo |
Málaga | Estadio Nuevo Carlos Tartiere |
| 10:15 AM PT11:15 AM MT12:15 PM CT1:15 PM ET17:15 GMT18:15 17:15 5:15 PM 19:15 KSA4:15 AM AET22:45 IST12:45 PM VEN21:15 UAE1:15 AM SST1:15 0:15 10:15 AM MST11:15 AM CST12:15 PM EST13:15 ET12:15 14:15 BRT13:15 12:15 PM CT |
13 | Real Valladolid |
Eibar | José Zorrilla |
| 12:30 PM PT1:30 PM MT2:30 PM CT3:30 PM ET19:30 GMT20:30 19:30 7:30 PM 21:30 KSA6:30 AM AET1:00 (+1) IST3:00 PM VEN23:30 UAE3:30 AM SST3:30 2:30 12:30 PM MST1:30 PM CST2:30 PM EST15:30 ET14:30 16:30 BRT15:30 2:30 PM CT |
13 | Real Zaragoza |
Mirandés | Estadio de la Romareda |
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