| September 2020 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sun. 13 | 1 | TBA | Getafe | Santiago Bernabéu | Postponed |
| Sun. 20 | 2 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT21:00 20:00 8:00 PM 22:00 KSA5:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT | Real Sociedad | Reale Arena | D 0-0 |
| Sat. 26 | 3 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT21:00 20:00 8:00 PM 22:00 KSA5:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT | Real Betis | Benito Villamarín | W 3-2 |
| Wed. 30 | 4 | 12:30 PM PT1:30 PM MT2:30 PM CT3:30 PM ET19:30 GMT21:30 20:30 8:30 PM 22:30 KSA5:30 AM AET1:00 (+1) IST3:00 PM VEN23:30 UAE3:30 AM SST3:30 2:30 12:30 PM MST1:30 PM CST2:30 PM EST15:30 ET14:30 16:30 BRT15:30 2:30 PM CT | Real Valladolid | Alfredo Di Stéfano | W 1-0 |
| October 2020 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sun. 4 | 5 | 7:00 AM PT8:00 AM MT9:00 AM CT10:00 AM ET14:00 GMT16:00 15:00 3:00 PM 17:00 KSA12:00 AM AET19:30 IST9:30 AM VEN18:00 UAE10:00 PM SST22:00 21:00 7:00 AM MST8:00 AM CST9:00 AM EST10:00 ET9:00 11:00 BRT10:00 9:00 AM CT | Levante | Estadio de la Cerámica | W 2-0 |
| Sat. 17 | 6 | 9:30 AM PT10:30 AM MT11:30 AM CT12:30 PM ET16:30 GMT18:30 17:30 5:30 PM 19:30 KSA2:30 AM AET22:00 IST12:00 PM VEN20:30 UAE12:30 AM SST0:30 23:30 9:30 AM MST10:30 AM CST11:30 AM EST12:30 ET11:30 13:30 BRT12:30 11:30 AM CT | Cádiz | Alfredo Di Stéfano | L 0-1 |
| Sat. 24 | 7 | 7:00 AM PT8:00 AM MT9:00 AM CT10:00 AM ET14:00 GMT16:00 15:00 3:00 PM 17:00 KSA12:00 AM AET19:30 IST9:30 AM VEN18:00 UAE10:00 PM SST22:00 21:00 7:00 AM MST8:00 AM CST9:00 AM EST10:00 ET9:00 11:00 BRT10:00 9:00 AM CT | Barcelona | Camp Nou | W 3-1 |
| Sat. 31 | 8 | 6:00 AM PT7:00 AM MT8:00 AM CT9:00 AM ET13:00 GMT14:00 13:00 1:00 PM 15:00 KSA12:00 AM AET18:30 IST8:30 AM VEN17:00 UAE9:00 PM SST21:00 20:00 6:00 AM MST7:00 AM CST8:00 AM EST9:00 ET8:00 10:00 BRT9:00 7:00 AM CT | Huesca | Alfredo Di Stéfano | W 4-1 |
| November 2020 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sun. 8 | 9 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 16:00 BRT16:00 1:00 PM CT | València | Estadio de Mestalla | L 1-4 |
| Sat. 21 | 10 | 7:15 AM PT8:15 AM MT9:15 AM CT10:15 AM ET15:15 GMT16:15 15:15 3:15 PM 17:15 KSA2:15 AM AET20:45 IST10:45 AM VEN19:15 UAE11:15 PM SST23:15 22:15 8:15 AM MST9:15 AM CST10:15 AM EST10:15 ET10:15 11:15 BRT11:15 8:15 AM CT | Villarreal | Estadio de la Cerámica | D 1-1 |
| Sat. 28 | 11 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 16:00 BRT16:00 1:00 PM CT | Alavés | Alfredo Di Stéfano | L 1-2 |
| December 2020 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sat. 5 | 12 | 7:15 AM PT8:15 AM MT9:15 AM CT10:15 AM ET15:15 GMT16:15 15:15 3:15 PM 17:15 KSA2:15 AM AET20:45 IST10:45 AM VEN19:15 UAE11:15 PM SST23:15 22:15 8:15 AM MST9:15 AM CST10:15 AM EST10:15 ET10:15 11:15 BRT11:15 8:15 AM CT | Sevilla | Ramon Sanchez Pizjuan | W 1-0 |
| Sat. 12 | 13 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 16:00 BRT16:00 1:00 PM CT | Atlético Madrid | Alfredo Di Stéfano | W 2-0 |
| Tue. 15 | 19 | 1:00 PM PT2:00 PM MT3:00 PM CT4:00 PM ET21:00 GMT22:00 21:00 9:00 PM 23:00 KSA8:00 AM AET2:30 (+1) IST4:30 PM VEN1:00 (+1) UAE5:00 AM SST5:00 4:00 2:00 PM MST3:00 PM CST4:00 PM EST16:00 ET16:00 17:00 BRT17:00 2:00 PM CT | Athletic Club | Alfredo Di Stéfano | W 3-1 |
| Sun. 20 | 14 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 16:00 BRT16:00 1:00 PM CT | Eibar | Estadio Municipal de Ipurua | W 3-1 |
| Wed. 23 | 15 | 10:45 AM PT11:45 AM MT12:45 PM CT1:45 PM ET18:45 GMT19:45 18:45 6:45 PM 20:45 KSA5:45 AM AET0:15 (+1) IST2:15 PM VEN22:45 UAE2:45 AM SST2:45 1:45 11:45 AM MST12:45 PM CST1:45 PM EST13:45 ET13:45 14:45 BRT14:45 11:45 AM CT | Granada | Alfredo Di Stéfano | W 2-0 |
| Wed. 30 | 16 | 12:30 PM PT1:30 PM MT2:30 PM CT3:30 PM ET20:30 GMT21:30 20:30 8:30 PM 22:30 KSA7:30 AM AET2:00 (+1) IST4:00 PM VEN0:30 (+1) UAE4:30 AM SST4:30 3:30 1:30 PM MST2:30 PM CST3:30 PM EST15:30 ET15:30 16:30 BRT16:30 1:30 PM CT | Elche | Estadio Manuel Martinez Valero | D 1-1 |
| January 2021 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sat. 2 | 17 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 16:00 BRT16:00 1:00 PM CT | Celta de Vigo | Alfredo Di Stéfano | W 2-0 |
| Sat. 9 | 18 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 16:00 BRT16:00 1:00 PM CT | Osasuna | Estadio El Sadar | D 0-0 |
| Sat. 23 | 20 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 16:00 BRT16:00 1:00 PM CT | Alavés | Estadio de Mendizorroza | W 4-1 |
| Sat. 30 | 21 | 7:15 AM PT8:15 AM MT9:15 AM CT10:15 AM ET15:15 GMT16:15 15:15 3:15 PM 17:15 KSA2:15 AM AET20:45 IST10:45 AM VEN19:15 UAE11:15 PM SST23:15 22:15 8:15 AM MST9:15 AM CST10:15 AM EST10:15 ET10:15 11:15 BRT11:15 8:15 AM CT | Levante | Alfredo Di Stéfano | L 1-2 |
| February 2021 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sat. 6 | 22 | 7:15 AM PT8:15 AM MT9:15 AM CT10:15 AM ET15:15 GMT16:15 15:15 3:15 PM 17:15 KSA2:15 AM AET20:45 IST10:45 AM VEN19:15 UAE11:15 PM SST23:15 22:15 8:15 AM MST9:15 AM CST10:15 AM EST10:15 ET10:15 11:15 BRT11:15 8:15 AM CT | Huesca | Estadio El Alcoraz | W 2-1 |
| Tue. 9 | 1 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 16:00 BRT16:00 1:00 PM CT | Getafe | Alfredo Di Stéfano | W 2-0 |
| Sun. 14 | 23 | 7:15 AM PT8:15 AM MT9:15 AM CT10:15 AM ET15:15 GMT16:15 15:15 3:15 PM 17:15 KSA2:15 AM AET20:45 IST10:45 AM VEN19:15 UAE11:15 PM SST23:15 22:15 8:15 AM MST9:15 AM CST10:15 AM EST10:15 ET10:15 11:15 BRT11:15 8:15 AM CT | València | Alfredo Di Stéfano | W 2-0 |
| Sat. 20 | 24 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 16:00 BRT16:00 1:00 PM CT | Real Valladolid | José Zorrilla | W 1-0 |
| March 2021 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Mon. 1 | 25 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 17:00 BRT16:00 1:00 PM CT | Real Sociedad | Alfredo Di Stéfano | D 1-1 |
| Sun. 7 | 26 | 7:15 AM PT8:15 AM MT9:15 AM CT10:15 AM ET15:15 GMT16:15 15:15 3:15 PM 17:15 KSA2:15 AM AET20:45 IST10:45 AM VEN19:15 UAE11:15 PM SST23:15 22:15 8:15 AM MST9:15 AM CST10:15 AM EST10:15 ET10:15 12:15 BRT11:15 8:15 AM CT | Atlético Madrid | Estadio Wanda Metropolitano | |
| Sat. 13 | 27 | 7:15 AM PT8:15 AM MT9:15 AM CT10:15 AM ET15:15 GMT16:15 15:15 3:15 PM 17:15 KSA2:15 AM AET20:45 IST10:45 AM VEN19:15 UAE11:15 PM SST23:15 22:15 8:15 AM MST9:15 AM CST10:15 AM EST10:15 ET10:15 12:15 BRT11:15 8:15 AM CT | Elche | Alfredo Di Stéfano | |
| Sat. 20 | 28 | 8:15 AM PT9:15 AM MT10:15 AM CT11:15 AM ET15:15 GMT16:15 15:15 3:15 PM 17:15 KSA2:15 AM AET20:45 IST10:45 AM VEN19:15 UAE11:15 PM SST23:15 22:15 8:15 AM MST9:15 AM CST10:15 AM EST11:15 ET10:15 12:15 BRT11:15 9:15 AM CT | Celta de Vigo | Abanca-Balaidos | |
| April 2021 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sun. 4 | 29 | TBA | Eibar | Alfredo Di Stéfano | |
| Sun. 11 | 30 | TBA | Barcelona | Alfredo Di Stéfano | |
| Wed. 21 | 31 | TBA | Cádiz | Ramón de Carranza | |
| Sun. 25 | 32 | TBA | Real Betis | Alfredo Di Stéfano | |
| Wed. 28 | 33 | TBA | Getafe | Coliseum Alfonso Perez | |
| May 2021 |
| Date | Matchday | Time | Opponent | Venue | Result |
| Sun. 2 | 34 | TBA | Osasuna | Alfredo Di Stéfano | |
| Sun. 9 | 35 | TBA | Sevilla | Alfredo Di Stéfano | |
| Wed. 12 | 36 | TBA | Granada | Los Cármenes | |
| Sun. 16 | 37 | TBA | Athletic Club | San Mamés | |
| Sun. 23 | 38 | TBA | Villarreal | Alfredo Di Stéfano | |
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