| Friday, 3 September 2021 |
| Time/Result | Home | Away | Venue |
| 1-1 |
Defensa y Justicia |
Central Cordoba | Estadio Norberto Tito Tomaghello |
| 2-0 |
Huracán |
Aldosivi | Estadio Tomas Adolfo Duco |
| Saturday, 4 September 2021 |
| Time/Result | Home | Away | Venue |
| 0-0 |
Atlético Tucumán |
Arsenal | Estadio Monumental Presidente Jose Fierro |
| 1-1 |
Lanús |
Sarmiento | Estadio Ciudad de Lanus - Nestor Diaz Perez |
| 1-1 |
Colón |
Newell's Old Boys | Estadio Brigadier General Estanislao Lopez |
| 1-1 |
Platense |
San Lorenzo | Estadio Ciudad de Vicente Lopez |
| 1-2 |
Rosario Central |
Boca Juniors | Estadio Dr. Lisandro de la Torre |
| Sunday, 5 September 2021 |
| Time/Result | Home | Away | Venue |
| 4-0 |
Godoy Cruz |
Gimnasia LP | Estadio Feliciano Gambarte |
| 0-0 |
Patronato |
Talleres de Cordoba | Estadio Presbitero Bartolome Grella |
| 0-0 |
Racing Club |
Banfield | Estadio Presidente Juan Domingo Peron |
| 1-1 |
River Plate |
Independiente | Estadio Monumental Antonio Vespucio Liberti |
| Monday, 6 September 2021 |
| Time/Result | Home | Away | Venue |
| 1-1 |
Estudiantes |
Argentinos Jrs. | Estadio Jorge Luis Hirschi |
| 4-0 |
Vélez Sarsfield |
Union Santa Fe | Estadio Jose Amalfitani |
| Monday, 13 September 2021 |
| Time/Result | Home | Away | Venue |
| 1-4 |
Aldosivi |
Godoy Cruz | Estadio Jose Maria Minella |
| 0-0 |
Sarmiento |
Huracán | Estadio Eva Peron de Junin |
| 0-1 |
Independiente |
Lanús | Estadio Libertadores de America |
| 1-1 |
San Lorenzo |
Racing Club | Estadio Pedro Bidegain |
| 0-0 |
Gimnasia LP |
Vélez Sarsfield | Estadio Juan Carmelo Zerillo |
| Tuesday, 14 September 2021 |
| Time/Result | Home | Away | Venue |
| 2-1 |
Talleres de Cordoba |
Platense | Estadio Mario Alberto Kempes |
| 0-0 |
Arsenal |
Colón | Estadio Julio Humberto Grondona |
| 2-0 |
Central Cordoba |
Atlético Tucumán | Estadio Unico Madre de Ciudades |
| 0-0 |
Boca Juniors |
Defensa y Justicia | Estadio Alberto Jose Armando |
| Wednesday, 15 September 2021 |
| Time/Result | Home | Away | Venue |
| 0-2 |
Union Santa Fe |
Estudiantes | Estadio 15 de Abril |
| 1-1 |
Argentinos Jrs. |
Patronato | Estadio Diego Armando Maradona |
| 1-2 |
Banfield |
Rosario Central | Estadio Florencio Sola |
| 1-4 |
Newell's Old Boys |
River Plate | Estadio Marcelo Alberto Bielsa |
| Saturday, 18 September 2021 |
| Time/Result | Home | Away | Venue |
| 1-1 |
Godoy Cruz |
Sarmiento | Estadio Feliciano Gambarte |
| 3-2 |
Vélez Sarsfield |
Aldosivi | Estadio Jose Amalfitani |
| 1-2 |
Racing Club |
Talleres de Cordoba | Estadio Presidente Juan Domingo Peron |
| 1-2 |
Atlético Tucumán |
Boca Juniors | Estadio Monumental Presidente Jose Fierro |
| Sunday, 19 September 2021 |
| Time/Result | Home | Away | Venue |
| 1-2 |
Patronato |
Estudiantes | Estadio Presbitero Bartolome Grella |
| 1-0 |
Colón |
Central Cordoba | Estadio Brigadier General Estanislao Lopez |
| 0-0 |
Platense |
Argentinos Jrs. | Estadio Ciudad de Vicente Lopez |
| 0-1 |
Huracán |
Independiente | Estadio Tomas Adolfo Duco |
| 1-0 |
River Plate |
Arsenal | Estadio Monumental Antonio Vespucio Liberti |
| Monday, 20 September 2021 |
| Time/Result | Home | Away | Venue |
| 1-0 |
Gimnasia LP |
Union Santa Fe | Estadio Juan Carmelo Zerillo |
| 1-2 |
Lanús |
Newell's Old Boys | Estadio Ciudad de Lanus - Nestor Diaz Perez |
| 1-0 |
Rosario Central |
San Lorenzo | Estadio Dr. Lisandro de la Torre |
| 0-0 |
Defensa y Justicia |
Banfield | Estadio Norberto Tito Tomaghello |
| Friday, 24 September 2021 |
| Time/Result | Home | Away | Venue |
| 0-1 |
Sarmiento |
Vélez Sarsfield | Estadio Eva Peron de Junin |
| 1-1 |
Estudiantes |
Platense | Estadio Jorge Luis Hirschi |
| Saturday, 25 September 2021 |
| Time/Result | Home | Away | Venue |
| 1-3 |
Aldosivi |
Gimnasia LP | Estadio Jose Maria Minella |
| 1-0 |
Arsenal |
Lanús | Estadio Julio Humberto Grondona |
| 4-1 |
Talleres de Cordoba |
Rosario Central | Estadio Francisco Cabases |
| 2-0 |
Banfield |
Atlético Tucumán | Estadio Florencio Sola |
| 1-3 |
Central Cordoba |
River Plate | Estadio Alfredo Terrera |
| Sunday, 26 September 2021 |
| Time/Result | Home | Away | Venue |
| 9:30 AM PT10:30 AM MT11:30 AM CT12:30 PM ET16:30 GMT17:30 16:30 4:30 PM 18:30 KSA3:30 AM AET22:00 IST12:00 PM VEN20:30 UAE12:30 AM SST0:30 23:30 9:30 AM MST10:30 AM CST11:30 AM EST12:30 ET11:30 13:30 BRT12:30 11:30 AM CT |
Union Santa Fe |
Patronato | Estadio 15 de Abril |
| 11:45 AM PT12:45 PM MT1:45 PM CT2:45 PM ET18:45 GMT19:45 18:45 6:45 PM 20:45 KSA5:45 AM AET0:15 (+1) IST2:15 PM VEN22:45 UAE2:45 AM SST2:45 1:45 11:45 AM MST12:45 PM CST1:45 PM EST14:45 ET13:45 15:45 BRT14:45 1:45 PM CT |
San Lorenzo |
Defensa y Justicia | Estadio Pedro Bidegain |
| 2:00 PM PT3:00 PM MT4:00 PM CT5:00 PM ET21:00 GMT22:00 21:00 9:00 PM 23:00 KSA8:00 AM AET2:30 (+1) IST4:30 PM VEN1:00 (+1) UAE5:00 AM SST5:00 4:00 2:00 PM MST3:00 PM CST4:00 PM EST17:00 ET16:00 18:00 BRT17:00 4:00 PM CT |
Independiente |
Godoy Cruz | Estadio Libertadores de America |
| 4:15 PM PT5:15 PM MT6:15 PM CT7:15 PM ET23:15 GMT0:15 23:15 11:15 PM 1:15 KSA10:15 AM AET4:45 (+1) IST6:45 PM VEN3:15 (+1) UAE7:15 AM SST7:15 6:15 4:15 PM MST5:15 PM CST6:15 PM EST19:15 ET18:15 20:15 BRT19:15 6:15 PM CT |
Boca Juniors |
Colón | Estadio Alberto Jose Armando |
| Monday, 27 September 2021 |
| Time/Result | Home | Away | Venue |
| 2:00 PM PT3:00 PM MT4:00 PM CT5:00 PM ET21:00 GMT22:00 21:00 9:00 PM 23:00 KSA8:00 AM AET2:30 (+1) IST4:30 PM VEN1:00 (+1) UAE5:00 AM SST5:00 4:00 2:00 PM MST3:00 PM CST4:00 PM EST17:00 ET16:00 18:00 BRT17:00 4:00 PM CT |
Argentinos Jrs. |
Racing Club | Estadio Diego Armando Maradona |
| 4:15 PM PT5:15 PM MT6:15 PM CT7:15 PM ET23:15 GMT0:15 23:15 11:15 PM 1:15 KSA10:15 AM AET4:45 (+1) IST6:45 PM VEN3:15 (+1) UAE7:15 AM SST7:15 6:15 4:15 PM MST5:15 PM CST6:15 PM EST19:15 ET18:15 20:15 BRT19:15 6:15 PM CT |
Newell's Old Boys |
Huracán | Estadio Marcelo Alberto Bielsa |
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